Improved Pain Management in Knee Osteoarthritis-related Surgeries
Evaluating the Effectiveness of Continuously Improved Pain Management in Knee Osteoarthritis-related Surgeries
1 other identifier
observational
714
1 country
1
Brief Summary
In recent years, pain management coordinated with enhanced recovery after surgery (ERAS) has been widely applied and rapidly developed in orthopedics, showing promising prospects. Since 2016, our hospital has used a series of continuously improved pain management schemes for patients with knee OA who underwent total knee arthroplasty (TKA), unicompartmental knee arthroplasty (UKA), and high tibial osteotomy (HTO). Here, we retrospectively analyze these patients' clinical data to compare the effects of different pain intervention measures during the perioperative period on postoperative pain, functional exercise, hospital stay, and prognosis of the three surgical methods in an attempt to provide a feasible solution for pain management of these patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2016
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 2, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
March 2, 2023
CompletedFirst Submitted
Initial submission to the registry
November 4, 2023
CompletedFirst Posted
Study publicly available on registry
November 9, 2023
CompletedNovember 9, 2023
November 1, 2023
6 years
November 4, 2023
November 8, 2023
Conditions
Outcome Measures
Primary Outcomes (2)
visual analogue score (VAS)
visual analogue score (VAS)
24 hours after surgery
visual analogue score (VAS)
visual analogue score (VAS)
72 hours after surgery
Secondary Outcomes (4)
Quadriceps muscle strength
24 hours after surgery
Quadriceps muscle strength
72 hours after surgery
Scope of activities to knee joint
24 hours after surgery
Scope of activities to knee joint
72 hours after surgery
Other Outcomes (4)
Self-Rating Anxiety Scale (SAS)
24 hours after surgery
Self-Rating Anxiety Scale (SAS)
72 hours after surgery
Self-Rating Depression Scale (SDS)
24 hours after surgery
- +1 more other outcomes
Study Arms (3)
Total knee arthroplasty (TKA)
Total knee arthroplasty
Unicompartmental knee arthroplasty (UKA)
Unicompartmental knee arthroplasty
High tibial osteotomy (HTO)
High tibial osteotomy
Interventions
propaganda and education on pain; Preemptive analgesia with celecoxib (200 mg bid) 2 days before surgery
Squeeze to expel blood (tourniquet); Before skin suture, 20 mL 0.5% ropivacaine was given subcutaneously for local infiltration anesthesia;
The intravenous analgesia pump was placed until 48 h after surgery;On the second day after surgery, celecoxib (200 mg bid) was administered orally, and buprenorphine transdermal patch was applied externally until hospital discharge;FNB catheter was placed under the guidance of ultrasound and connected with an analgesic pump, the anesthesia lasted until 48 h after surgery ‡
Eligibility Criteria
The medical records of 714 patients (142 men, 40 women; mean age: 38.5 years; age range: 18-64 years) with moderate or severe knee OA who had undergone TKA (n=551), UKA (n=92), or HTO (n=71) in a group of joint surgery at Sichuan Provincial People's Hospital between March 2016 and February 2022 were retrospectively analyzed. Clinical data, including age, weight, height, anesthesia grade, surgery, and time, as well as continuously improved perioperative pain management measures, were recorded.
You may qualify if:
- first knee surgery were 50-80 years old had complete clinical and follow-up data
You may not qualify if:
- American Society of Anesthesiologists Physical Status grade≥4 comorbidity with three or more systemic diseases long-term anxiety and depression, contraindications of painkillers, long-term alcoholism, or taking painkillers concomitant limb pain caused by spinal degeneration
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Peng Liulead
Study Sites (1)
Sichuan Provincial People's Hospital
Chengdu, Sichuan, 610072, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
November 4, 2023
First Posted
November 9, 2023
Study Start
March 1, 2016
Primary Completion
March 2, 2022
Study Completion
March 2, 2023
Last Updated
November 9, 2023
Record last verified: 2023-11