Tandem Occlusion After Emergent Stenting in Acute Ischemic Stroke
TOESIS
1 other identifier
interventional
110
1 country
1
Brief Summary
In acute ischemic stroke due to tandem occlusion, the emergent stenting has recently become an endovascular treatment option combining with mechanical thrombectomy to achieve recanalization. However, the data on the beneficial endovascular management of tandem occlusion in two circulations is still limited. The purpose of our study was to compare the improvement of clinical outcome between two circulations after emergent stenting at 3 months.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Dec 2020
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2020
CompletedFirst Submitted
Initial submission to the registry
November 1, 2023
CompletedFirst Posted
Study publicly available on registry
November 7, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
November 30, 2025
CompletedJune 13, 2024
June 1, 2024
4.8 years
November 1, 2023
June 11, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
The favorable 3-month outcome rate
The favorable 3-month outcome rate was accessed by modified Rankin Score (mRS), which comprised of included good (mRS 0 - ≤ 2) and fair (mRS 3).
3 months
Secondary Outcomes (1)
The symptomatic intracerebral hemorrhage rate
24 hours after emergent stenting
Study Arms (2)
Emergent Stenting in Anterior circulation
EXPERIMENTALEmergent Carotid Stenting in acute ischemic stroke caused by tandem occlusions
Emergent Stenting in Posterior circulation
EXPERIMENTALEmergent Extracranial Vertebral Stenting in acute ischemic stroke caused by tandem occlusions
Interventions
Emergent Stenting in acute ischemic stroke caused by tandem occlusions
Eligibility Criteria
You may qualify if:
- Age \> 18 years old
- Premorbid mRS \< 2
- NIHSS \> 5
- ASPECTS ≥ 5 or pc-ASPECTS ≥ 5
You may not qualify if:
- Onset to treatment time \> 24 hours
- Loss to follow up after discharge
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Can Tho Stroke International Services Hospital
Can Tho, 900000, Vietnam
Related Publications (2)
Allard J, Delvoye F, Pop R, Labreuche J, Maier B, Marnat G, Sibon I, Zhu F, Lapergue B, Consoli A, Spelle L, Denier C, Richard S, Piotin M, Gory B, Mazighi M; ETIS Investigators. 24-Hour Carotid Stent Patency and Outcomes After Endovascular Therapy: A Multicenter Study. Stroke. 2023 Jan;54(1):124-131. doi: 10.1161/STROKEAHA.122.039797. Epub 2022 Dec 21.
PMID: 36542074BACKGROUNDHan N, Ma L, Zhao L, Xu G, Jia Y, Wang H. The Dilator-Dotter technique can successfully treat tandem lesions of posterior circulation. Medicine (Baltimore). 2024 Jan 26;103(4):e37044. doi: 10.1097/MD.0000000000037044.
PMID: 38277540BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Cuong Tran Chi, Doctor
Can Tho Stroke International Services General Hospital
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director
Study Record Dates
First Submitted
November 1, 2023
First Posted
November 7, 2023
Study Start
December 1, 2020
Primary Completion
September 30, 2025
Study Completion
November 30, 2025
Last Updated
June 13, 2024
Record last verified: 2024-06
Data Sharing
- IPD Sharing
- Will not share