Examining the Effect of Piano Playing Training on Fine Motor Skills in Parkinson's Patients

NCT06120192 | Suspended

• 1 other identifier: 8407-21-SMC
• Study Type: interventional
• Target: 3
• Locations: 1 country
• Sites: 1

Brief Summary

Piano playing may provide an engaging and accessible setting for finger and wrist movement training. Moreover, it has been found effective for improving manual dexterity and upper-limb function in other neurologic disorders, such as stroke and additionally beneficial for cognitive and psychosocial support in Parkinson's disease. However, no study has examined the effect of piano playing on dexterity in Parkinson's disease. The aim of this study is to test the efficacy of a novel piano-based training program on fine motor function in patients with PD. Participants with Parkinson's disease will take part in an individually tailored 6-week piano training program, combining weekly supervised training sessions (6x60 min altogether), with three independent at-home weekly 30 minutes practice sessions (18x30 altogether). Participants will receive a piano MIDI keyboard for home use during the study.

Conditions

Parkinson Disease

Keywords

music; piano; dexterity

Outcome Measures

Primary Outcomes (4)

• Box and block test

  Number of blocks that can be moved over a barrier using the hand / arm in one minute

  First meeting, last meeting (after 6 weeks)

• 9 Hole peg test

  Time taken to insert 9 pegs into holes and then remove them

  First meeting, last meeting (after 6 weeks)

• Synergy index

  Calculated from a force ramp production task using the fingers with force sensors

  First meeting, last meeting (after 6 weeks)

• Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS) motor parts II (patient questionnaire) - parts 2.4 to 2.7 and III (motor examination) - parts 3.3 and 3.4

  Standard questionnaire used in Parkinson's disease. Higher scores indicate more impairment. Maximum score for each part is 4, so overall for the 6 parts the maximum score is 24.

  First meeting, last meeting (after 6 weeks)

Secondary Outcomes (5)

• Quantitative Digitography - Average strike duration

  First meeting, last meeting (after 6 weeks)

• Quantitative Digitography - Coefficient of variation strike duration

  First meeting, last meeting (after 6 weeks)

• Quantitative Digitography - Average interval between strikes (in seconds)

  First meeting, last meeting (after 6 weeks)

• Quantitative Digitography - Coefficient of variation of interval between strikes

  First meeting, last meeting (after 6 weeks)

• Quantitative assessment of piano performance progress

  First meeting, last meeting (after 6 weeks)

Study Arms (1)

Research group

EXPERIMENTAL

Receives the full piano training

Behavioral: Piano

Interventions

Piano BEHAVIORAL

Receives the piano training

Research group

Eligibility Criteria

• Age: 40 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Idiopathic Parkinson's Disease patients
• Hoehn and Yahr stages I to III
• Self-reports of some dexterity difficulties

You may not qualify if:

• Participation in an ongoing clinical study or clinical study within 30 days prior to this study
• Atypical parkinsonian syndrome or secondary parkinsonism (e.g., due to drugs, metabolic neurogenetic disorders, encephalitis, cerebrovascular disease, or other degenerative disease), or other neurologic conditions influencing upper limb movement
• Significant psychiatric symptoms or history
• Significant or recent experience in piano playing (participants who are proficient piano players, or had studied piano for more than 3 years in the past, or for shorter periods in the last 5 years)
• Other significant fine motor skills (e.g., high proficiency in playing another musical instrument, video games, etc.)
• Mini Mental status examination (MMSE) score below 25
• Significant sensory deficits, e.g., hearing or sight impairment
• Unstable medical disorder
• Significant postural or action tremor, moderate dyskinesia

Sponsors & Collaborators

• Tel Aviv University: lead
• Sheba Medical Center: collaborator

Study Sites (1)

Tel Aviv University

Tel Aviv, 6997801, Israel

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: Open label feasibility study

Study Record Dates

• First Submitted: October 26, 2023
• First Posted: November 7, 2023
• Study Start: August 22, 2022
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: November 7, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: ICF
• Time Frame: Upon publication
• Access Criteria: Open to all

Locations

IL (1)