Cardiac Injury With Convulsive Status Epilepticus

NCT06119919 | Unknown

• 1 other identifier: Cardiac injury and epilepsy
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

1. 1.Determine the impact of cardiac injury on clinical profile, cardiac evaluation and outcome in patients hospitalized with convulsive status epilepticus (CSE).
2. 2.Analyze the frequency of cardiac rhythm and conduction abnormalities related to seizures and determine risk factors and associated clinical characteristics.
3. 3.Analyse ECG abnormalities and changes in HR in epileptic seizures since such disturbances might be a factor in SUDEP
4. 4.Assessment of levels of cardiac enzymes in patients with status epilepticus

Conditions

Convulsive Status EPILEPTICUS

Outcome Measures

Primary Outcomes (4)

• cardiac injury and convulsive status epilepticus

  Determine the impact of cardiac injury on clinical profile and outcome in patients with convulsive status epilepticus

  baseline

• Cardiac injury and convulsive status epilepticus

  Analyze the frequency of cardiac rhythm and conduction abnormalities

  Baseline

• Cardiac injury and convulsive status epilepticus

  Analyze ECG abnormalities and heart rate changes

  Baseline

• Cardiac injury and convulsive status epilepticus

  Assessment of levels of cardiac enzymes in patients with status epilepticus

  Baseline

Eligibility Criteria

• Age: 1 Month - 16 Years
• Sex: all
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

all children admitted in Assiut University Hospitals Pediatrics department from 1 month to 16 years with convulsive status epilepticus

You may qualify if:

• children aged 1 month to 16 years presented with Convulsions
• convulsions lasts more than 5 minutes or recurrent seizures without regaining consciousness in-between

You may not qualify if:

• Patients with hepatic diseases
• patients with chronic renal illness
• patients with endocrinal diseases
• patients with musculoskeletal abnormalities
• children with sepsis
• congenital heart disease, myocarditis, myocardial disease, or arrhythmias; and children who survived cardiac surgery

Sponsors & Collaborators

• Assiut University: lead

Related Publications (10)

• Fogarasi A, Janszky J, Tuxhorn I. Autonomic symptoms during childhood partial epileptic seizures. Epilepsia. 2006 Mar;47(3):584-8. doi: 10.1111/j.1528-1167.2006.00472.x.

  PMID: 16529626 BACKGROUND

• Janszky J, Fogarasi A, Toth V, Magalova V, Gyimesi C, Kovacs N, Schulz R, Ebner A. Peri-ictal vegetative symptoms in temporal lobe epilepsy. Epilepsy Behav. 2007 Aug;11(1):125-9. doi: 10.1016/j.yebeh.2007.04.015. Epub 2007 Jun 20.

  PMID: 17584534 BACKGROUND

• Widdess-Walsh P, Kotagal P, Jeha L, Wu G, Burgess R. Multiple auras: clinical significance and pathophysiology. Neurology. 2007 Aug 21;69(8):755-61. doi: 10.1212/01.wnl.0000267650.50269.5d.

  PMID: 17709707 BACKGROUND

• Baumgartner C, Lurger S, Leutmezer F. Autonomic symptoms during epileptic seizures. Epileptic Disord. 2001 Sep;3(3):103-16.

  PMID: 11679301 BACKGROUND

• Nei M, Ho RT, Sperling MR. EKG abnormalities during partial seizures in refractory epilepsy. Epilepsia. 2000 May;41(5):542-8. doi: 10.1111/j.1528-1157.2000.tb00207.x.

  PMID: 10802759 BACKGROUND

• Natelson BH, Suarez RV, Terrence CF, Turizo R. Patients with epilepsy who die suddenly have cardiac disease. Arch Neurol. 1998 Jun;55(6):857-60. doi: 10.1001/archneur.55.6.857.

  PMID: 9626779 BACKGROUND

• Woodruff BK, Britton JW, Tigaran S, Cascino GD, Burritt MF, McConnell JP, Ravkilde J, Molgaard H, Andreasen F, Dam M, Jaffe AS. Cardiac troponin levels following monitored epileptic seizures. Neurology. 2003 May 27;60(10):1690-2. doi: 10.1212/01.wnl.0000065881.46964.4f.

  PMID: 12771269 BACKGROUND

• Tigaran S, Molgaard H, McClelland R, Dam M, Jaffe AS. Evidence of cardiac ischemia during seizures in drug refractory epilepsy patients. Neurology. 2003 Feb 11;60(3):492-5. doi: 10.1212/01.wnl.0000042090.13247.48.

  PMID: 12578934 BACKGROUND

• Chin RF, Neville BG, Peckham C, Bedford H, Wade A, Scott RC; NLSTEPSS Collaborative Group. Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study. Lancet. 2006 Jul 15;368(9531):222-9. doi: 10.1016/S0140-6736(06)69043-0.

  PMID: 16844492 BACKGROUND

• Mitchell WG. Status epilepticus and acute serial seizures in children. J Child Neurol. 2002 Jan;17 Suppl 1:S36-43. doi: 10.1177/08830738020170010501.

  PMID: 11918461 BACKGROUND

MeSH Terms

Conditions

Status Epilepticus

Condition Hierarchy (Ancestors)

Seizures; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Christin Emad, resident

CONTACT

01281872843; christinemadragheb@gmail.com

Mohammed Mahrous Eltellawy, professor

CONTACT

01003486595; eltellawy270@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: 71515,Assiut

Study Record Dates

• First Submitted: October 27, 2023
• First Posted: November 7, 2023
• Study Start: January 1, 2024
• Primary Completion: January 1, 2025
• Study Completion: March 1, 2025
• Last Updated: November 7, 2023

Record last verified: 2023-11