Microbiome and Host Susceptibility in Severe Pneumonia, a Prospective, Multicenter, Cohort Study
MASS
Identification of Lung and Intestinal Microbiome and Host Susceptibility in Severe Pneumonia, a Prospective, Multicenter Cohort Study
1 other identifier
observational
2,000
1 country
15
Brief Summary
This study was a prospective multicenter cohort of severe pneumonia. And by collecting clinical samples to clarify the correlation between lung microbiome, intestinal microbiome, host susceptibility, and prognosis of severe pneumonia patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2023
Typical duration for all trials
15 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 25, 2023
CompletedFirst Submitted
Initial submission to the registry
October 24, 2023
CompletedFirst Posted
Study publicly available on registry
November 2, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2026
August 7, 2025
August 1, 2025
3.3 years
October 24, 2023
August 4, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
The correlation between lung microbiome and disease prognosis
1\. Identification of microbial gene profiles; 2. Analysis of host health dynamics and trends; 3. Identification of host gene mutations; 4. Preliminary model construction; 5. Model optimization and evaluation.
60 days
Study Arms (1)
Severe pneumonia
Definition of severe pneumonia: New infection that meets one of the following definitions: the patient receives mechanical ventilation (invasive or non-invasive) due to acute respiratory failure, with a PEEP level of 5cm or above; The patient receives high flow oxygen therapy with a FiO2 of 50% or more and a PaO2: FiO2 ratio of less than 300; The patient receives oxygen treatment with a partial respiration mask with an air storage bag, provided that PaO2 is lower than the pre-specified indicator.
Interventions
Eligibility Criteria
Overall, the investigators will include all severe pneumonia patients transferred to the ICU, including community acquired pneumonia, hospital acquired pneumonia, and ventilator-associated pneumonia.
You may qualify if:
- \. New lung infection that meets one of the following definitions: the patient receives mechanical ventilation (invasive or non-invasive) due to acute respiratory failure, with a PEEP level of 5cm or above; Patients receiving high flow oxygen therapy with a FiO2 of 50% or more and a PaO2: FiO2 ratio below 300
You may not qualify if:
- Expected length of stay in ICU is less than 1 day
- Pregnant
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (15)
First Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310000, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310000, China
Shulan (Hangzhou) hospital
Hangzhou, China
Tongde Hospital of Zhejiang Province
Hangzhou, China
the First People's Hospital of Huzhou
Huzhou, China
The First Hospital of Jiaxing
Jiaxing, China
Lanxi Hospital of Traditional Chinese Medicine
Lanxi, China
Lishui People's Hospital
Lishui, China
The First People's Hospital of Pinghu
Pinghu, China
Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
Taizhou, China
Wenzhou Central Hospital
Wenzhou, China
Xi'an People's Hospital (Xi'an No.4 Hospital)
Xi'an, China
Henan Provincial People's Hospital
Zhengzhou, China
The Fifth Clinical Medical College of Henan University of Chinese Medicine
Zhengzhou, China
The Second Affiliated Hospital of Zhengzhou University
Zhengzhou, China
Biospecimen
Bronchoalveolar lavage fluid, sputum, feces, peripheral blood
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Lingtong Huang, M.D.
Zhejiang University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Doctor
Study Record Dates
First Submitted
October 24, 2023
First Posted
November 2, 2023
Study Start
September 25, 2023
Primary Completion (Estimated)
December 31, 2026
Study Completion (Estimated)
December 31, 2026
Last Updated
August 7, 2025
Record last verified: 2025-08