NCT06114030

Brief Summary

Deep margin elevation (DME) is a non-invasive restorative technique to relocate the deep cervical margin to a supragingival position using resin composite. This retrospective multicenter practice-based study will assess the long-term clinical performance and periodontal health of teeth restored with CAD-CAM crowns with or without DME. Patients who will receive CAD-CAM lithium disilicate (LD) crowns with or without DME between 2013 and 2023 at multiple private practices will be included. When indicated, DME will be performed using resin-based restoration. Clinical assessment of the crowns and supporting periodontal structures will be performed following the modified United States Public Health Service (USPHS) criteria. Intra-oral photographs, periapical and bitewing radiographs will be taken for further assessment by three evaluators. Kaplan Meier survival analyses will be performed.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
560

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Mar 2023

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2023

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

October 17, 2023

Completed
16 days until next milestone

First Posted

Study publicly available on registry

November 2, 2023

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 30, 2023

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

January 30, 2024

Completed
Last Updated

November 2, 2023

Status Verified

October 1, 2023

Enrollment Period

10 months

First QC Date

October 17, 2023

Last Update Submit

November 1, 2023

Conditions

Outcome Measures

Primary Outcomes (2)

  • The survival rate of teeth restored with or without DME and crowns.

    Number of survived crowns in the presence or absence of DME

    10 years

  • Number of failed crowns in the presence or absence of DME

    10 years

Secondary Outcomes (3)

  • Change from baseline in pocket depth

    10 years

  • Change from baseline in bleeding of probing

    10 years

  • Periodontal responses in response to deep (subgingival) margins

    10 years

Study Arms (1)

Deep margin elevation followed by crowns

OTHER

Teeth restored with DME and crowns

Procedure: Deep margin elevation with composite resin and Lithium disilicate glass-ceramic crowns

Interventions

Restoration of the deep margin by composite restorations such as: Filtek Supreme XTE, Tetric EvoCeram, Estelite Sigma Qquick followed by Lithium disilicate glass-ceramic CAD/CAM crowns (IPS e.max CAD).

Also known as: Filtek Supreme XTE (3M ESPE, Seefeld, Germany), Tetric EvoCeram (Ivoclar Vivadent AG, Schaan, Lichtenstein), Estelite Sigma Qquick (Tokuyama, Tokyo, Japan), IPS e.max CAD (Ivoclar Vivadent AG, Schaan, Lichtenstein)
Deep margin elevation followed by crowns

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • adult patient and indication for crown with or without DME.

You may not qualify if:

  • poor oral hygiene and active periodontal disease.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Sharjah

Sharjah city, 7724, United Arab Emirates

RECRUITING

MeSH Terms

Conditions

Dental CariesTooth FracturesProsthesis Failure

Interventions

Composite ResinsTetric EvoCeram

Condition Hierarchy (Ancestors)

Tooth DemineralizationTooth DiseasesStomatognathic DiseasesTooth InjuriesWounds and InjuriesPostoperative ComplicationsPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Resins, SyntheticPlasticsPolymersMacromolecular SubstancesDental MaterialsBiomedical and Dental MaterialsManufactured MaterialsTechnology, Industry, and Agriculture

Study Officials

  • Ahmed M Aziz, PhD

    University of Sharjah

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Ahmed M Aziz, PhD

CONTACT

Sama Suliman, MS

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

October 17, 2023

First Posted

November 2, 2023

Study Start

March 1, 2023

Primary Completion

December 30, 2023

Study Completion

January 30, 2024

Last Updated

November 2, 2023

Record last verified: 2023-10

Data Sharing

IPD Sharing
Will not share

Locations