Depressive and Anxiety Disorders in Patients With Chronic Liver Diseases

NCT06113029 | Unknown

• 1 other identifier: Depression and liver
• Study Type: observational
• Target: 118
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this observational study is to learn about the prevalence of depressive and anxiety disorders among patients with chronic liver diseases

Conditions

Depression, Anxiety

Keywords

Depression; Anxiety; liver

Outcome Measures

Primary Outcomes (1)

• Number of participants that experienced depressive or anxiety disorders

  Each participant will be asked to fill items of questionnaires like The Beck Depression inventor, The Hamilton Rating Scale for Anexity and Rand SF-36 Questionnaire

  Baseline

Study Arms (2)

Healthy group

Participants not known to have neither chronic liver diseases nor Psychiatric disorders

Diagnostic Test: The Hamilton Rating Scale for Anxiety; Diagnostic Test: The Beck Depression inventory; Diagnostic Test: Rand SF-36 Questionnaire

Diseased group

Participants known to have chronic liver diseases

Diagnostic Test: The Hamilton Rating Scale for Anxiety; Diagnostic Test: The Beck Depression inventory; Diagnostic Test: Rand SF-36 Questionnaire

Interventions

The Hamilton Rating Scale for Anxiety DIAGNOSTIC_TEST

The scale consists of 14 items, each defined by a series of symptoms, and measures both psychic anxiety (mental agitation and psychological distress) and somatic anxiety (physical complaints related to anxiety).

Diseased group; Healthy group

The Beck Depression inventory DIAGNOSTIC_TEST

one of the most widely used instruments for measuring the severity of depression

Diseased group; Healthy group

Rand SF-36 Questionnaire DIAGNOSTIC_TEST

The SF-36 measures eight scales: physical functioning (PF), role physical (RP), bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role emotional (RE), and mental health (MH). Component analyses showed that there are two distinct concepts measured by the SF-36: a physical dimension, represented by the Physical Component Summary (PCS), and a mental dimension, represented by the Mental Component Summary (MCS). All scales do contribute in different proportions to the scoring of both PCS and MCS measures

Diseased group; Healthy group

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with chronic liver diseases

You may qualify if:

• patients admitted or attending at Rajhi university hospital with chronic liver disease including: viral (hepatitis B and C), autoimmune (primary biliary cirrhosis, primary sclerosing cholangitis and autoimmune hepatitis), non-alcoholic steatohepatitis, Morbus Wilson and cryptogenic CLD.
• age group above 18 years old.

You may not qualify if:

• patients with chronic liver disease with other psychiatric disorders other than depression and anxiety.
• patients with acute complication of chronic liver disease.
• patients with chronic liver disease who underwent liver transplation.
• patients with chronic liver disease under antiviral therapy.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Salma Ashraf Mohamed Badr

Asyut, 71745, Egypt

Location

Related Publications (3)

• Vahia VN. Diagnostic and statistical manual of mental disorders 5: A quick glance. Indian J Psychiatry. 2013 Jul;55(3):220-3. doi: 10.4103/0019-5545.117131. No abstract available.

  PMID: 24082241 BACKGROUND

• Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005 Jun;62(6):593-602. doi: 10.1001/archpsyc.62.6.593.

  PMID: 15939837 BACKGROUND

• Huang X, Liu X, Yu Y. Depression and Chronic Liver Diseases: Are There Shared Underlying Mechanisms? Front Mol Neurosci. 2017 May 8;10:134. doi: 10.3389/fnmol.2017.00134. eCollection 2017.

  PMID: 28533742 BACKGROUND

MeSH Terms

Conditions

Depression; Anxiety Disorders

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: October 26, 2023
• First Posted: November 2, 2023
• Study Start: December 1, 2023
• Primary Completion: September 30, 2024
• Study Completion: October 1, 2024
• Last Updated: November 27, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will share

Locations

EG (1)