NCT06112509

Brief Summary

The purpose of this study is to evaluate the vestibular effects of gamma-knife radiosurgery, as part of the treatment of vestibular schwannoma.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Feb 2024

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 20, 2023

Completed
12 days until next milestone

First Posted

Study publicly available on registry

November 1, 2023

Completed
4 months until next milestone

Study Start

First participant enrolled

February 20, 2024

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2024

Completed
Last Updated

September 19, 2024

Status Verified

September 1, 2024

Enrollment Period

9 months

First QC Date

October 20, 2023

Last Update Submit

September 5, 2024

Conditions

Keywords

vestibularschwannomaradiosurgerygamma-knifeneurinomaacoustic

Outcome Measures

Primary Outcomes (2)

  • Description of vestibular function with videonystagmography before gamma-knife radiosurgery, as part of the treatment of vestibular schwannoma.

    Videonystagmography: Results of caloric tests = Intervestibular deficit (in percentage)

    1 month before gamma-knife radiosurgery

  • Description of vestibular function with vidéonystagmoscopy before gamma-knife radiosurgery, as part of the treatment of vestibular schwannoma.

    Videonystagmography: Results of caloric tests = Intervestibular deficit (in percentage)

    After gamma-knife radiosurgery at 6 month or 12 month or 18 month or 2 years or 3 years depending on the history of the treatment

Secondary Outcomes (2)

  • Description of vestibular symptoms before gamma-knife radiosurgery as part of the treatment of vestibular schwannoma.

    1 month before gamma-knife radiosurgery

  • Description of vestibular symptoms after gamma-knife radiosurgery as part of the treatment of vestibular schwannoma.

    After gamma-knife radiosurgery at 6 month or 12 month or 18 month or 2 years or 3 years depending on the history of the treatment

Study Arms (1)

Radiosurgery

OTHER
Other: Vestibular exam

Interventions

Interrogation, videonystagmoscopy, videonystagmography, video-head-impulse-test

Radiosurgery

Eligibility Criteria

Age18 Years - 90 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Men and women aged 18 to 90 included
  • Subject who benefited from gamma-knife radiosurgery as part of the treatment of vestibular schwannoma
  • Non-opposition of the subject to participate in the study
  • Affiliation to a French social security scheme or beneficiary of such a scheme

You may not qualify if:

  • Subject with another vestibular pathology
  • Subject who did not benefit from a vestibular assessment before treatment with gamma-knife radiosurgery
  • Legal incapacity or limited legal capacity
  • Subject unlikely to cooperate in the study and/or weak cooperation anticipated by the investigator
  • Subject without health insurance

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHU de Besançon

Besançon, France

RECRUITING

MeSH Terms

Conditions

Neuroma, AcousticNeurilemmoma

Condition Hierarchy (Ancestors)

Neuroendocrine TumorsNeuroectodermal TumorsNeoplasms, Germ Cell and EmbryonalNeoplasms by Histologic TypeNeoplasmsNeuromaNerve Sheath NeoplasmsNeoplasms, Nerve TissueCranial Nerve NeoplasmsNervous System NeoplasmsNeoplasms by SitePeripheral Nervous System NeoplasmsVestibulocochlear Nerve DiseasesRetrocochlear DiseasesEar DiseasesOtorhinolaryngologic DiseasesOtorhinolaryngologic NeoplasmsCranial Nerve DiseasesNervous System Diseases

Study Officials

  • DAMON Veronique, MD

    CHU de Besançon

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Model Details: Prognostic cohort study
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 20, 2023

First Posted

November 1, 2023

Study Start

February 20, 2024

Primary Completion

November 1, 2024

Study Completion

November 1, 2024

Last Updated

September 19, 2024

Record last verified: 2024-09

Locations