Role of MSCT Volumetry in Assessment of Brain Atrophy in Septic Patients

NCT06112119 | Unknown FDA Device

• 1 other identifier: sepsis and brain atrophy
• Study Type: observational
• Target: 55
• Locations: 0 countries
• Sites: N/A

Brief Summary

assessment of brain atrophy associated with septic ICU patients by using MSCT Volumetry

Conditions

Sepsis-Associated Encephalopathy

Outcome Measures

Primary Outcomes (1)

• - Correlation between sepsis and brain volume reduction . - Determine the role of the CT scan in assess brain volume in acute phase of sepsis and it,s influences in improvement activities of daily living.

  \- Determine the role of the CT scan in assess brain volume in acute phase of sepsis and it,s influences in improvement activities of daily living after discharge from ICU.

  follow up through 10 days after admission in ICU

Study Arms (1)

cohort

patients \>16y with sepsis associated with disturbance in conscious level, the first braun CT scan will be routinely performed on admission, the second further brain CT Scan will be obtained whenever prolonged disturbance of consciousness will be detected.

Device: MSCT

Interventions

MSCT DEVICE

Using Semi-automatic MSCT Volumetry in assessment of brain atrophy associated with septic ICU patients

cohort

Eligibility Criteria

• Age: 16 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

All the patients will be included within ehs inclusion criteria after giving informed consent from patients or from the hospital board to review patients' medical records, it will include: * Full history taking. * Clinically provisinal diagnosis . * Blood and bacterial culture was performed at the time of admission for all patients . * Firstly All studies were performed by using a CT device. CT scans measuring brain volume using BCR which is the width between anterior horn of the bilateral lateral ventricle divided by that of the cerebrum at the same height at the caudate nucleus that measuring in particular frontal lobe volume . * Also using Evan index which is the width between anterior horn of the bilateral lateral ventricles divided by cranial lumen at the same height . * When increase BCR and EI ,decrease in brain volume ocurr.

You may qualify if:

• patients \>16years old with sepsis associated with disturbance in conscious level admitted to ICU

You may not qualify if:

• Age\< 16y Brain death Hematological disease Malignant disease Hypoxemia Error in automatic tissue classification Motion artifac

Sponsors & Collaborators

• Assiut University: lead

Related Publications (1)

• Nakae R, Sekine T, Tagami T, Murai Y, Kodani E, Warnock G, Sato H, Morita A, Yokota H, Yokobori S. Rapidly progressive brain atrophy in septic ICU patients: a retrospective descriptive study using semiautomatic CT volumetry. Crit Care. 2021 Nov 29;25(1):411. doi: 10.1186/s13054-021-03828-7.

  PMID: 34844648 BACKGROUND

Related Links

• retrospective study using semi automatic volumetry

MeSH Terms

Conditions

Sepsis-Associated Encephalopathy

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Nada mohamed abdelmoneim

  Assiut University

  PRINCIPAL INVESTIGATOR

• sherif mohamed abdelaal

  Assiut University

  STUDY DIRECTOR

• samy abdelaziz

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Nada mohamed abdelmoneim

CONTACT

01097151396; abdelmoneimnada44@gmail.com

sherif mohamed abdelaal

CONTACT

01003691110; sherifabdelal@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer

Study Record Dates

• First Submitted: October 27, 2023
• First Posted: November 1, 2023
• Study Start: November 1, 2023
• Primary Completion: November 1, 2024
• Study Completion: December 30, 2024
• Last Updated: November 1, 2023

Record last verified: 2023-10