NCT06111599

Brief Summary

Thermovision-controlled lumbar sympathetic blockade in chronic limb-threatening ischemia treatment

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
4mo left

Started Oct 2023

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress89%
Oct 2023Aug 2026

First Submitted

Initial submission to the registry

October 21, 2023

Completed
1 day until next milestone

Study Start

First participant enrolled

October 22, 2023

Completed
10 days until next milestone

First Posted

Study publicly available on registry

November 1, 2023

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2024

Completed
2.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2026

Expected
Last Updated

November 1, 2023

Status Verified

October 1, 2023

Enrollment Period

9 months

First QC Date

October 21, 2023

Last Update Submit

October 26, 2023

Conditions

Outcome Measures

Primary Outcomes (4)

  • Change From Baseline EuroQoL-5 Dimension (EQ-5D) Value 3m

    EQ-5D-5L self-care, usual activities, pain/discomfort and anxiety/depression

    3 months follow-up

  • Change From Baseline EuroQoL-5 Dimension (EQ-5D) Value 6m

    EQ-5D-5L self-care, usual activities, pain/discomfort and anxiety/depression

    6 months follow-up

  • Change From Baseline Visual Analog Pain Scale (VAS) of Back Pain 3m

    Change From Baseline Visual Analog Pain Scale (VAS) of Back Pain 3m measured by VAS 10 point measurement

    3 months follow-up

  • Change From Baseline Visual Analog Pain Scale (VAS) of Back Pain 6m

    Change From Baseline Visual Analog Pain Scale (VAS) of Back Pain 6m measured by VAS 10 point measurement

    6 months follow-up

Study Arms (3)

Group A

EXPERIMENTAL

Proximal arterial obliteration

Procedure: lumbar sympathetic blockade

Group B

EXPERIMENTAL

Distal arterial obliteration

Procedure: lumbar sympathetic blockade

Group C

EXPERIMENTAL

Complex arterial obliteration

Procedure: lumbar sympathetic blockade

Interventions

Skiascopic-guided lumbar sympathetic blockade with the administration of local anesthetic

Group AGroup BGroup C

Eligibility Criteria

Age20 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Chronic limb-threatening ischemia-Patients with chronic leg pain for at least 6 months with intensity (VAS \>=5)
  • those who (only if a signature was obtainable), or whose legal guardian,fully understood the clinical trial -details and signed the informed consent form

You may not qualify if:

  • Chronic Venous Insufficiency
  • women with positive a pregnancy tests before the trial or who planned to become pregnant within the following 3 years
  • other patients viewed as inappropriate by the staff
  • disagreement with participation in the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Europainclinics

Košice, 04011, Slovakia

RECRUITING

Related Publications (1)

  • Kocan L, Rajtukova V, Rasiova M, Kocanova H, Hudak R, Vaskova J, Satnik V, Martuliak I, Hudak M. Infrared monitoring-based optimization of interventional lumbar sympathectomy outcomes evaluation in peripheral vascular disease patients: Experimental trial thermovision-guided lumbar sympathectomy. Medicine (Baltimore). 2025 Feb 14;104(7):e41524. doi: 10.1097/MD.0000000000041524.

MeSH Terms

Conditions

Chronic Limb-Threatening Ischemia

Condition Hierarchy (Ancestors)

Peripheral Arterial DiseaseAtherosclerosisArteriosclerosisArterial Occlusive DiseasesVascular DiseasesCardiovascular DiseasesPeripheral Vascular DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and SymptomsIschemia

Central Study Contacts

Ladislav Kočan, MD, PhD, FIPP

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Patients with chronic limb-threatening ischemia
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 21, 2023

First Posted

November 1, 2023

Study Start

October 22, 2023

Primary Completion

August 1, 2024

Study Completion (Estimated)

August 31, 2026

Last Updated

November 1, 2023

Record last verified: 2023-10

Locations