Cardiogenic Acute Pulmonary Edema in Subjects Over 75 Years Old: Impact of Non-invasive Ventilation on Mortality

NCT06107257 | Unknown

• 1 other identifier: 8785
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

People aged over 75 represent almost 10% of the general population, and 12 to 14% of patients consulting emergency departments. Cardiogenic acute pulmonary edema (APO) is a very common reason for admission to the emergency room. The effectiveness of non-invasive ventilation (NIV) has been demonstrated during the management of PAO and would allow, compared to medical treatment alone, a more rapid improvement in clinical and gasometric parameters as well as a reduction in the need for ventilation. orotracheal intubation. On the other hand, the impact of NIV on mortality in cardiogenic PAO seems poorly defined, with lower levels of scientific evidence regarding a possible benefit in terms of survival, particularly in the elderly population. The objective of this study is to determine whether the use of NIV in cardiogenic PAO in elderly subjects admitted to the emergency room of Strasbourg University Hospital would have an impact in terms of mortality up to 6 months compared to medical treatment alone.

Conditions

Cardiogenic Pulmonary Edema

Keywords

Cardiogenic Pulmonary Edema; Acute pulmonary edema; Non-invasive ventilation

Outcome Measures

Primary Outcomes (1)

• Survival Analysis

  6 months after cardiogenic acute pulmonary edema

Eligibility Criteria

• Age: 76 Years+
• Sex: all
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult subject (\> 75 years) with a diagnosis of cardiogenic PAO treated at Strasbourg University Hospital between January 1, 2021 and October 31, 2021

You may qualify if:

• Adult subject (\> 75 years old)
• Admission to the NHC emergency room between January 1, 2021 and October 31, 2021
• Diagnosis of cardiogenic PAO
• Indication of NIV according to current recommendations
• Subject not opposing the reuse of their data for scientific research purposes.

You may not qualify if:

• Subject having expressed his opposition to the reuse of his data for scientific research purposes.
• Presence of an absolute contraindication to NIV
• Respiratory distress due to pneumonia or other diagnosis
• RT-PCR Sars Cov 2 positive in emergency

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Gériatrie - Service de Soins de Soins Médicaux et de Réadaptation - CHU de Strasbourg - France

Strasbourg, 67091, France

RECRUITING

Related Publications (1)

• Haddi L, Valerio L, Bilbault P, Kaltenbach G, Schmitt E. Effect of noninvasive ventilation on 6-month mortality in patients with acute cardiogenic pulmonary oedema: a retrospective study dedicated to older persons. Intern Emerg Med. 2025 Sep;20(6):1753-1760. doi: 10.1007/s11739-025-04012-3. Epub 2025 Jun 15.

  PMID: 40517332 DERIVED

Central Study Contacts

Elise SCHMITT, MD

CONTACT

33 3 88 11 58 84; elise.schmitt@chru-strasbourg.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 24, 2023
• First Posted: October 30, 2023
• Study Start: February 1, 2023
• Primary Completion: December 1, 2023
• Study Completion: December 31, 2023
• Last Updated: October 30, 2023

Record last verified: 2023-10

Locations

FR (1)