NCT06104943|Active Not Recruiting
Stockholm hyperTRIglyceridemia REGister (STRIREG) Study
STRIREG
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STRIREG
Sponsor study identifier
observational
3,607,819
0 countries
N/A
Study Start
January 1, 2000
Actual (reported)Primary Completion
December 31, 2021
Actual (reported)Study Completion
December 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The STRIREG study is a retrospective longitudinal general population-based register study including all individuals who had had at least one plasma Tg measurement between 1st January 2000 and 31st December 2021 at Karolinska University Laboratory or Unilabs AB in Region Stockholm (population 2.41 million 2021). The exclusion criteria were a lack of a unique Swedish personal identification number (PIN). The index population consisted of 1,460,184 individuals between the age 0 and 107 years. The index population was extended to form the complete cohort (n=3,607,819) by associating the parents and the siblings (n=2,147,635) to the indexes by interlinkage of personal identification numbers via the Multi-Generation register (see below). The study baseline for the index population was defined as the date for participant's first Tg measurement.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 1, 2000
Actual (reported)December 31, 2021
Actual (reported)October 23, 2023
Actual (reported)October 27, 2023
Actual (reported)December 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Mortality
All cause mortality
Jan 1 2000 to Dec 31 2021
Cardiovascular mortality
Cardiovascular mortality
Jan 1 2000 to Dec 31 2021
Pancreatitis
Pancreatitis
Jan 1 2000 to Dec 31 2021
Major cardiovascular event (MACE)
Major cardiovascular event (MACE)
Jan 1 2000 to Dec 31 2021
Myocardial infarction
Jan 1 2000 to Dec 31 2021
Stroke
Jan 1 2000 to Dec 31 2021
Peripheral artery disease
Jan 1 2000 to Dec 31 2021
Type 2 diabetes
Jan 1 2000 to Dec 31 2021
Cardiac revascularization
Jan 1 2000 to Dec 31 2021
All individuals who had had at least one plasma Triglyceride measurement between 1st January 2000 and 31st December 2021 at Karolinska University Laboratory or Unilabs AB in Stockholm County in Sweden.
Parents and the siblings to the index patients by interlinkage of personal identification numbers via the Swedish Multi-Generation register.
First degree relatives with a diagnosis of Cardiovascular disease.
First degree relatives with a diagnosis of pancreatitis.
Populationbased cohort originating from Stockholm County. with all individuals who had had at least one plasma Triglyceride measurement between 1st January 2000 and 31st December 2021 at Karolinska University Laboratory or Unilabs AB in Stockholm County Sweden. The first degree relatives are parents and siblings to the index patients identified through the Swedish Multi-Generation Register.
Contact the study team to confirm eligibility.
3,607,819 participants (actual enrollment reported by the registry).
First Submitted
October 23, 2023
First Posted
October 27, 2023
Study Start
January 1, 2000
Actual (reported)Effects of FXR Activation on Hepatic Lipid and Glucose Metabolism
First degree relatives with a diagnosis of type 2 diabetes.
First degree relatives with hypertriglyceridemia
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Primary Completion
December 31, 2021
Actual (reported)Study Completion
December 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 27, 2023
Record last verified: 2023-09
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Source: ClinicalTrials.gov.
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