Coronary Computed Tomography Versus Invasive Angiography for Non-ST Elevation Acute Coronary Syndrome
TRACTION
Team-based Interventional Triage in Acute Coronary Syndrome Based on Non-Invasive Computed Tomography Coronary Angiography - a Randomized Trial
1 other identifier
interventional
2,300
1 country
6
Brief Summary
Coronary computed tomography angiography (CCTA) is a widely accepted initial diagnostic test for individuals suspected of having chronic coronary syndromes. However, there is limited evidence supporting its use in the acute setting. So far, no large-scale randomized trial has examined the performance of CCTA as an alternative to invasive coronary angiography (ICA) in individuals with non-ST-segment elevation myocardial infarction (NSTEACS). If CCTA were to replace ICA as a routine procedure for individuals with NSTEACS, it could reduce the risk of complications related to ICA, improve patient comfort, expedite decision-making, and reduce healthcare expenses and interhospital transfers.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Oct 2023
Longer than P75 for not_applicable
6 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 28, 2023
CompletedStudy Start
First participant enrolled
October 1, 2023
CompletedFirst Posted
Study publicly available on registry
October 26, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
October 1, 2036
February 19, 2025
February 1, 2025
3 years
September 28, 2023
February 14, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Number of participants with a combined endpoint of major adverse cardiac events
All-cause mortality, non-fatal myocardial infarction, hospitalization with refractory angina, or hospitalization with heart failure.
At 1 year.
Secondary Outcomes (7)
Number of participants with a the individual composites of the primary outcome
At 1 year.
Number of participants with cardiovascular death
At 1 year.
Number of participants with unplanned coronary revascularization
At 1 year.
Health-related Quality of life
At 1 year.
Angina symptom burden
At 1 year.
- +2 more secondary outcomes
Study Arms (2)
Coronary computed tomography angiography + team-based interventional triage
ACTIVE COMPARATORConventional invasive coronary angiography
OTHERInterventions
Participants will be examined with CCTA during admission.
Patients will be examined with conventional standard-of-care ICA.
The CCTA will be discussed at a coronary CT-team conference to establish the treatment strategy and provide guidance for any necessary interventional procedure.
Eligibility Criteria
You may qualify if:
- Admitted with non-ST-segment elevation myocardial infarction or unstable angina pectoris and an indication for subacute ICA
- Elevated troponin or ischemic electrocardiographic changes
- Written informed consent
You may not qualify if:
- Instability requiring acute or emergent ICA
- History of percutaneous coronary intervention or coronary artery bypass grafting
- Estimated glomerular filtration rate \< 30 mL/min/1.73m2
- Probable type 2 acute myocardial infarction
- Severe valvular heart disease as primary diagnosis or potential need for valve intervention
- History of spontaneous coronary artery dissection
- Expected poor quality of the CCTA
- Prior CCTA or ICA during index admission or within 1 week
- Known allergy to beta-blockers or contrast agent
- Pregnant or nursing
- Previously randomized in this trial
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Rigshospitalet, Denmarklead
- University of Copenhagencollaborator
Study Sites (6)
Herlev and Gentofte Hospital
Copenhagen, Hellerup, 2900, Denmark
Bispebjerg Hospital
Bispebjerg, Denmark
Rigshospitalet
Copenhagen, Denmark
Zealand University Hospital
Copenhagen, Denmark
North Zealand Hospital
Hillerød, Denmark
Hvidovre Hospital
Hvidovre, Denmark
Related Publications (1)
Sorgaard MH, Kristensen AT, Eskesen K, Kofoed KF, Linde JJ, Kelbaek H, Ottesen M, Neland K, Kragelund C, Bertelsen MLN, Hove JD, Mork G, Kristiansen OP, Engstrom T, Lonborg JT, Kuhl JT, Risom SS, Blanche P, Olsen NT. Coronary computed tomography angiography versus invasive coronary angiography for interventional triage in acute coronary syndrome: Design of the randomized TRACTION trial. Am Heart J. 2025 Dec 6;294:107325. doi: 10.1016/j.ahj.2025.107325. Online ahead of print.
PMID: 41360328DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
September 28, 2023
First Posted
October 26, 2023
Study Start
October 1, 2023
Primary Completion (Estimated)
October 1, 2026
Study Completion (Estimated)
October 1, 2036
Last Updated
February 19, 2025
Record last verified: 2025-02
Data Sharing
- IPD Sharing
- Will share
Data will be shared upon reasonable request and uploaded to a repository after the trial has been concluded.