Prospective Radiomics Study for Breast Cancer
Prospective Study of MRI-based Radiomics in Breast Cancer
1 other identifier
observational
121
1 country
1
Brief Summary
The goal of this prospective study is to develop MRI-based models representing tumor microenvironment in participants with invasive breast cancer. The main purpose of this study is to analyze the association of diffusion-, T2-, and dynamic contrast-enhanced T1-weighted images of 3T MRI before treatment with the immunohistochemical reactivity of tumor microenvironment including the extracellular matrix and immune cells of core-needle biopsy specimens For this purpose, investigators extract 16145 radiomic features from the intratumoral and peritumoral regions on MRI of participants with invasive breast cancer before treatment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jun 2020
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 30, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
August 30, 2023
CompletedFirst Submitted
Initial submission to the registry
October 11, 2023
CompletedFirst Posted
Study publicly available on registry
October 23, 2023
CompletedOctober 23, 2023
October 1, 2023
1.9 years
October 11, 2023
October 18, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
The signal intensity of Magnetic Resonance Images for tumor microenvironment
The percentage of diffusion-, T2-, and dynamic contrast-enhanced T1-weighted images correlated with the percentage of immune cells infiltrating tumor microenvironment of breast tumor tissue
Baseline, pre-surgery
Interventions
MRI based assessment of tumor microenvironment in breast cancer mass
Eligibility Criteria
The study population should fulfill the following criteria as follows:(a) histologically confirmed invasive breast cancer, (b) participant consent, and (c) MRI performed before treatment
You may qualify if:
- Diagnosed with invaseiv breast cancer
You may not qualify if:
- Diagnosed with other cancers
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Bo Kyoung Seo
Ansan, 15355, South Korea
Related Publications (1)
Kim ES, Ham S, Seo BK, Lee JY, Sun W, Jeon M, Joo M, Park S, Wang S, Lee B, Lee HY, Bae MS, Cho KR, Woo OH, Song SE, Kim SY. Optimized prediction of breast cancer tumor microenvironment using MRI-based intratumoral and peritumoral radiomics: a prospective study. Front Oncol. 2025 Nov 6;15:1654508. doi: 10.3389/fonc.2025.1654508. eCollection 2025.
PMID: 41278298DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Bo Kyoung Seo, MD., PhD
Korea University Ansan Hospital
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 3 Years
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
October 11, 2023
First Posted
October 23, 2023
Study Start
June 1, 2020
Primary Completion
April 30, 2022
Study Completion
August 30, 2023
Last Updated
October 23, 2023
Record last verified: 2023-10