Quantitative Assessment of Lid Margin Vascularity Using SS-OCTA

NCT06091722 | Unknown

• 1 other identifier: 20230801LMBFD
• Study Type: observational
• Target: 150
• Locations: 0 countries
• Sites: N/A

Brief Summary

To explore an optimized scan technique for the detection of lid margin vasculature

Conditions

Ss-octa; Lid Margin Blood Flow Density; MGD

Outcome Measures

Primary Outcomes (1)

• LMBFD

  Lid margin blood flow density

  Immediately after ssocta

Study Arms (3)

1

Mild group, the scores of both clinicians were ≤ grade 1

2

Moderate group, one doctor scored grade 2, and the other doctor scored 1\~2;

3

Moderate group, one doctor scored grade 2, and the other doctor scored 1\~2;

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

MGD or normal patients who could cooperate with dry eye evaluation and SSOCTA examination in the dry eye Clinic of the Eye Hospital of Wenzhou Medical University were enrolled.

You may qualify if:

• The MGD patients were aged \>\_20 years and were diagnosed according to Chinese MGD diagnostic criteria,11 including dry eye symptoms, and at least one of the following signs: (1) poor meibum expressibility or quality; (2) at least one of eyelid margin abnormalities (lid margin irregularity, plugging of the gland orifice, vascular engorgement/telangiectasia, and anterior replacement of the mucocutaneous junction. Normal subjects were defined as adults without any dry eye symptoms and lid margin abnormality.

You may not qualify if:

• (1) subjects with ocular diseases or conditions known to affect the anatomy of the anterior segment, such as acute ocular inflammation, a history of eyelid surgery, contact lens wear within two weeks, and/or eyelid trauma; (2) subjects with of history of systemic or topical medications that might cause ocular congestion; (3) subjects with severe systemic illness or pregnancy; and (4) subjects who were difficult to cooperate with examination, resulting the obtained images were not sufficiently clear for automatic analysis.

Sponsors & Collaborators

• Wenzhou Medical University: lead

Central Study Contacts

Man HU

CONTACT

13738069080; 64344308@qq.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 15, 2023
• First Posted: October 19, 2023
• Study Start: October 20, 2023
• Primary Completion: December 1, 2023
• Study Completion: February 28, 2024
• Last Updated: October 19, 2023

Record last verified: 2023-10

Data Sharing

• IPD Sharing: Will not share