NCT06087159

Brief Summary

This study record describes a two-phase of clinical trial study. The first phase is a pilot study phase (to study feasibility and efficacy of the intervention), and the second phase is an effectiveness study phase (a fully powered evaluation study to test the intervention effectiveness). This proposal seeks to develop and test a new mHealth intervention, the mHealth Toolkit for Wellness \& Empowering Lives of School Community (mWEL) in Uganda. The mWEL-digial toolkit is a preventive intervention tool for teachers and parents as a self-help support modality. Caregivers who need support in navigating the toolkit will be supported by peer-community health workers (P-CHWs).

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,180

participants targeted

Target at P75+ for not_applicable

Timeline
22mo left

Started Nov 2024

Longer than P75 for not_applicable

Geographic Reach
1 country

2 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress47%
Nov 2024Jan 2028

First Submitted

Initial submission to the registry

October 11, 2023

Completed
6 days until next milestone

First Posted

Study publicly available on registry

October 17, 2023

Completed
1 year until next milestone

Study Start

First participant enrolled

November 1, 2024

Completed
2.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2027

Expected
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 31, 2028

Last Updated

April 20, 2026

Status Verified

April 1, 2026

Enrollment Period

2.7 years

First QC Date

October 11, 2023

Last Update Submit

April 16, 2026

Conditions

Outcome Measures

Primary Outcomes (3)

  • Change in Universal Mental Health Literacy Scale Score

    The Universal Mental Health Literacy Scale comprises 21 items asking respondents to indicate their knowledge of various aspects regarding mental health. Items are rated on Yes/No or 5-point Likert scales. The total score is produced by mean of all item scores and ranges from 1-5 or % correct knowledge; higher scores indicate greater mental health literacy

    Baseline, Month 5

  • Change in PHQ-9 Score

    The Patient Health Questionnaire-9 (PHQ-9) is a widely used self-administered tool designed to screen, diagnose, and monitor the severity of depression in individuals. It consists of nine questions that align directly with the diagnostic criteria for major depressive disorder in the DSM-5. Each item asks about the frequency of specific depressive symptoms experienced over the past two weeks (on a 0 to 3 point Likert scales), such as low mood, loss of interest, sleep problems, fatigue, appetite changes, feelings of worthlessness, trouble concentrating, psychomotor changes, and thoughts of self-harm or suicide. The total score ranges from 0 to 27, with higher scores indicating more severe depression. Severity is typically interpreted as follows: 0-4: None to minimal depression 5-9: Mild depression 10-14: Moderate depression 15-19: Moderately severe depression 20-27: Severe depression

    Baseline, Month 5

  • Change in GAD-7 Anxiety Score

    The Generalized Anxiety Disorder 7-item scale (GAD-7) is a brief, self-administered questionnaire designed to screen for and assess the severity of generalized anxiety disorder (GAD) symptoms over the past two weeks. The scale is rated on a 0 to 3 point Likert scales). The total GAD-7 score ranges from 0 to 21, with higher scores indicating greater anxiety severity. Severity is commonly interpreted as: 0-4: Minimal anxiety 5-9: Mild anxiety 10-14: Moderate anxiety 15-21: Severe anxiety Less than 55 = None to slight depression 55.0-59.9 = Mild depression 60.0-69.9 = Moderate depression 70 and over = Severe depression

    Baseline, Month 5

Study Arms (2)

mWEL Intervention (Phase 1 and Phase 2)

EXPERIMENTAL

Teachers or parents of children in participating schools who are randomly assigned to receive the mWEL intervention.

Behavioral: mHealth Toolkit for Wellness & Empowering Lives of School Community (mWEL)

Control (Phase 1 and Phase 2)

NO INTERVENTION

Teachers or parents of children in participating schools who are randomly assigned to the control arm.

Interventions

mWEL-App is a preventive intervention tool for teachers and parents as a self-help support. It integrates three key mental health presentive service functions: i) comprehensive screen to assess mental health (anxiety, depression), stress, and related contextual risks; ii) a tailored strength and weakness profile/report with recommendations to promote self-awareness and mental health knowledge; and iii) tailored evidence-based strategies and additional support and clinical resources to improve skills in stress management, emotion regulation, and maintain mental wellness. mWEL will be designed as a self-administered tool. Participating parents and teachers can access to mWEL app after they sign up for an account. Intervention participants will have access to the App anytime within a 3-5 month study period.

mWEL Intervention (Phase 1 and Phase 2)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Teaching in recruited schools.
  • At least 18 years old.
  • At least 18 years old.
  • Have a child aged 6-14 years.

You may not qualify if:

  • Evidence of psychopathology or cognitive impairment severe enough to preclude giving consent, or completing the survey instruments or the focus group of the study.
  • Parents/Teachers/Caregivers who are not in one of our recruited primary school
  • Participants under the age of 18
  • Participant who does not speak English and Luganda will not be able to participate

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Study Site

Kampala, Uganda

RECRUITING

Study Site

Nakaseke, Uganda

RECRUITING

MeSH Terms

Conditions

DepressionAnxiety Disorders

Interventions

Health

Condition Hierarchy (Ancestors)

Behavioral SymptomsBehaviorMental Disorders

Intervention Hierarchy (Ancestors)

Population Characteristics

Study Officials

  • Keng-Yen Huang, PhD, MPH

    NYU Langone Health

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Keng-Yen Huang, PhD, MPH

CONTACT

Demy Kamboukos, Ph.D.

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 11, 2023

First Posted

October 17, 2023

Study Start

November 1, 2024

Primary Completion (Estimated)

August 1, 2027

Study Completion (Estimated)

January 31, 2028

Last Updated

April 20, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

The de-identified participant data from the final research dataset used in the published manuscript will be shared upon reasonable request beginning 9 months and ending 36 months following article publication or as required by a condition of awards and agreements supporting the research provided the investigator who proposes to use the data executes a data use agreement with NYU Langone Health. Requests may be directed to: Keng-Yen.Huang@nyulangone.org The protocol and statistical analysis plan will be made available on Clinicaltrials.gov only as required by federal regulation or as a condition of awards and agreements supporting the research.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
Beginning 9 months and ending 36 months following article publication or as required by a condition of awards and agreements supporting the research.
Access Criteria
The investigator who proposed to use the data will be granted access upon reasonable request. Requests should be directed to Keng-Yen.Huang@nyulangone.org. To gain access, data requestors will need to sign a data access agreement.

Locations