Salivary and Serum Leptin Levels in Oral Lichen Planus Patients: A Case-control Study.

NCT06078579 | Completed Results DMC

• 1 other identifier: 20723
• Study Type: observational
• Target: 78
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the levels of leptin in both saliva and serum samples of patients diagnosed with oral lichen.

Conditions

Oral Lichen Planus; Leptin Levels

Keywords

salivary; Serum

Outcome Measures

Primary Outcomes (1)

• Serum Leptin Level

  Assessment of serum leptin levels in in oral lichen planus patients

  Baseline

Secondary Outcomes (1)

• Salivary Leptin Levels

  Baseline

Study Arms (2)

Oral lichen planus patients

Assessment of salivary and serum leptin levels

Diagnostic Test: Leptin

Healthy control group

Assessment of salivary and serum leptin levels

Diagnostic Test: Leptin

Interventions

Leptin DIAGNOSTIC_TEST

Assessment of salivary and serum leptin levels in oral lichen planus patients and healthy controls

Healthy control group; Oral lichen planus patients

Eligibility Criteria

• Age: 30 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

OLP patients and healthy controls were selected will be selected from "out-patient clinic" of Oral Medicine, Periodontology and Oral Diagnosis Department ;Faculty of Dentistry, Cairo university and from "out-patient" of Boulak El Dakroor general hospital.

You may qualify if:

• Ages for both sexes fall between 30 and 70.
• Symptomatic OLP has been diagnosed clinically and verified histologically.
• Participants who sign a written consent form after being fully informed about the study.

You may not qualify if:

• Treatment with a systemic or locally administered systemic medication within the previous three months before the commencement of the research.
• Patients now taking or who have just stopped taking an NSAIDs (both steroidal and non steroidal) for pain or inflammation.
• Patients who have been diagnosed with a malignant tumor or tumors.
• Women who are expecting or nursing.
• Inmates, the mentally ill, the elderly, etc, all fall into this category.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo university

Cairo, Egypt

Location

Related Publications (2)

• Aryanian Z, Shirzadian A, Hatami P, Dadras H. High Incidence of Metabolic Syndrome Components in Lichen Planus Patients: A Prospective Cross-Sectional Study. Int J Clin Pract. 2022 Jan 31;2022:7184678. doi: 10.1155/2022/7184678. eCollection 2022.

  PMID: 35685585 BACKGROUND

• Matarese G, Moschos S, Mantzoros CS. Leptin in immunology. J Immunol. 2005 Mar 15;174(6):3137-42. doi: 10.4049/jimmunol.174.6.3137.

  PMID: 15749839 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

ELISA

MeSH Terms

Conditions

Lichen Planus, Oral

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Lichen Planus; Lichenoid Eruptions; Skin Diseases, Papulosquamous; Skin Diseases; Skin and Connective Tissue Diseases

Results Point of Contact

• Title: Dr. Bahaa Mahmoud Fawzy
• Organization: Cairo university

bahaamust66@gmail.com

+201033559646

Study Officials

• Weam Ah Rashwan, PHD

  Cairo University

  STUDY DIRECTOR

• Olfat Ga Shaker, PHD

  Cairo University

  STUDY DIRECTOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dentist

Study Record Dates

• First Submitted: September 27, 2023
• First Posted: October 12, 2023
• Study Start: December 30, 2023
• Primary Completion: November 30, 2024
• Study Completion: December 30, 2024
• Last Updated: March 30, 2025
• Results First Posted: March 30, 2025

Record last verified: 2025-03

Locations

EG (1)