Effects of Transcranial Oscillatory Direct Current Stimulation on the Functions of Cerebral Cortex in Healthy Subjects

NCT06076044 | Recruiting

• 1 other identifier: FirstHebei
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

To investigate the effect of transcranial oscillatory direct current stimulation on functions of cerebral cortex (cortical excitability and frequency of eeg) in healthy subjects

Conditions

Transcranial Direct Current Stimulation; Motor Evoked Potential; Healthy Subjects

Outcome Measures

Primary Outcomes (2)

• MEP

  Motor evoked potentials of the right abductor pollicis brevis were collected

  before treatment and 20, 30, 40, 50, 60 minutes after treatment

• Power Spectral Density of EEG

  The rest state EEG of the subjects was collected

  before treatment and right after treatment

Study Arms (1)

healthy subjects

EXPERIMENTAL

healthy male subjects aged 20-30 years

Device: toDCS 2mA 1Hz; Device: toDCS 2mA 10Hz; Device: tDCS 1mA; Device: sham

Interventions

toDCS 2mA 1Hz DEVICE

The subgroup treated by transcranial oscillatory direct current stimulation of 2mA and 1Hz.

healthy subjects

toDCS 2mA 10Hz DEVICE

The subgroup treated by transcranial oscillatory direct current stimulation of 2mA and 10Hz.

healthy subjects

tDCS 1mA DEVICE

The subgroup treated by transcranial direct current stimulation of 1mA.

healthy subjects

sham DEVICE

The subgroup treated by sham stimulation.

healthy subjects

Eligibility Criteria

• Age: 20 Years - 30 Years
• Gender Eligibility Details: The participant eligibility is not based on self-representation of gender identity. The investigators apply the gender eligibility to avoid the influence of female's menstrual cycle.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy male
• Age ranges from 20 to 30 years old
• No history of neurological or psychiatric diseases, no history of chronic illness
• No positive results were found in the examination of the nervous system
• All right-handed according to Edinburgh Handedness Inventory
• The subjects voluntarily participated in this study and signed an informed consent form

You may not qualify if:

• Individuals with severe illnesses
• Previous history of brain surgery or epilepsy
• Individuals who experience changes in physical condition during the experiment
• Individuals with metal implants, such as pacemakers, DBS therapists, stents, etc
• Alcoholics

Sponsors & Collaborators

• The First Hospital of Hebei Medical University: lead

Study Sites (1)

the First Hospital of Hebei Medical University

Shijiazhuang, Hebei, 050031, China

RECRUITING

Central Study Contacts

Yuan Xing, PhD, MD

CONTACT

+8618633888925; leaf_trunks@163.com

Nan Zhang, PhD, MD

CONTACT

+8618633888974; jlx88cn@163.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Attending, Department of Neurology, Principal Investigator

Study Record Dates

• First Submitted: September 21, 2023
• First Posted: October 10, 2023
• Study Start: June 1, 2023
• Primary Completion: November 30, 2023
• Study Completion: March 15, 2024
• Last Updated: February 23, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)