Comparison of Analgesia Efficacy of Transversus Abdominis Plane Block and Posterior Approach Quadratus Lumborum Block

NCT06075498 | Completed

• 1 other identifier: 22/III
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

Prostate cancer is the second most common cancer and the fifth in cancer-related deaths. Open radical retropubic prostatectomy is the most common surgical treatment for localized prostate cancer. Open radical retropubic prostatectomy is associated with moderate pain. Severe pain in the postoperative period affects the length of hospital stay and morbidity. Multimodal analgesia applications for the management of postoperative pain are the main component of post-surgical recovery. Different analgesia modalities, including systemic opioid use and neuraxial analgesia, have been used for pain control after retropubic radical prostatectomy. Side effects of systemic and intrathecal opioids limit the potential benefits of these agents. Transversus abdominis plane block and quadratus lumborum block are blocks that can be used for postoperative analgesia in the abdominal and pelvic regions. There is no study in the literature comparing the efficacy of these two blocks for postoperative analgesia in open radical retropubic prostatectomy and their effects on narcotic consumption.

Conditions

Acute Post-operative Pain; Nerve Block; Prostate Cancer

Keywords

quadratus lumborum block, transversus abdominis plane block

Outcome Measures

Primary Outcomes (1)

• To compare the two groups analgesic efficacy and opioid consumption within 24 hours postoperatively.

  Comparing the analgesic effectiveness of the transversus abdominis plane block and posterior approach quadratus lumborum block and opioid intake and patient pain within 24 hours after surgery

  24 hours postoperatively

Secondary Outcomes (1)

• Duration of sensory block, opioid-related side effects (postoperative nausea and vomiting, itching, sedation), patient satisfaction and complications related to the block.

  24 hours postoperatively

Study Arms (2)

transversus abdominis plane block

ACTIVE COMPARATOR

The group that underwent bilateral transversus abdominis plane block with 0.375 mg 20 ml bupivacaine on each side after open retropubic prostatectomy operations

Procedure: transversus abdominis plane block,

quadratus lumborum plane block

ACTIVE COMPARATOR

The group that underwent bilateral quadratus lumborum plane block with 0.375 mg 20 ml bupivacaine on each side after open retropubic prostatectomy operations

Procedure: transversus abdominis plane block,

Interventions

transversus abdominis plane block, PROCEDURE

2 different plan blocks; 1. transversus plane block 2. quadratus lumborum plane block

Also known as: quadratus lumborum plane block

quadratus lumborum plane block; transversus abdominis plane block

Eligibility Criteria

• Age: 18 Years - 70 Years
• Gender Eligibility Details: Male patients will be included in the study, as there are patients who underwent prostate surgery.
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ASA I-II-II patients who can adapt to the pain assessment scale will be included in the study.

You may not qualify if:

• Patients under 18 years of age
• ASA IV patients
• patients with known allergy to analgesic drugs
• patients with any contraindications for the regional technique (patients with coagulation disorders, injection site infection, patients allergic to local anesthetics)
• patients with chronic analgesic use
• body mass patients with an index over 35 kg/m2

Sponsors & Collaborators

• Muğla Sıtkı Koçman University: lead

Study Sites (1)

Mugla Sitki Kocman Training and Research Hospital

Muğla, 48000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative; Prostatic Neoplasms

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Genital Neoplasms, Male; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Prostatic Diseases; Male Urogenital Diseases

Study Officials

• basak altiparmak

  Mugla Sitki Kocman University Department of Anesthesia

  STUDY CHAIR

• ahmet pinarbasi

  Mugla Sitki Kocman University Department of Anesthesia

  STUDY CHAIR

• ilker akarken

  Mugla sitki kocman department of urology

  STUDY CHAIR

• bakiye ugur

  Mugla Sitki Kocman Universty of Anaesthesia

  STUDY CHAIR

• eylem yasar

  Mugla Sitkı Kocman Training and research hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Postoperative follow-up was evaluated by a research assistant blind to the procedure. groups 1 and 2 were presented to the Outcome Assessor.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist

Model Details: patients who underwent open retropubic prostatectomy

Study Record Dates

• First Submitted: January 24, 2022
• First Posted: October 10, 2023
• Study Start: February 5, 2022
• Primary Completion: May 21, 2023
• Study Completion: June 21, 2023
• Last Updated: April 26, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)