IonMAN II Trial- Early Feasibility Study of the IoNIR Ridaforolimus-Eluting Coronary Stent System

NCT06071702 | Suspended DMC FDA Device

• 1 other identifier: IoNIR-002
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This is a prospective, multi-center, single-arm, open-label, early feasibility study to provide preliminary evidence for the safety and efficacy of the novel IoNIR stent system

Conditions

Coronary Stenosis; Coronary Artery Disease

Outcome Measures

Primary Outcomes (2)

• In-stent Late Loss (LL)

  In-stent Late Loss (LL) at 13 months assessed by quantitative coronary angiography (QCA) (Minimal Lumen Diameter (MLD) post-procedure - MLD follow-up (US patients only))

  13 months

• Target Lesion Failure

  Target Lesion Failure (composite of cardiovascular death, target vessel-related myocardial infarction, or ischemia-driven target lesion revascularization)

  1 year

Secondary Outcomes (36)

• Major adverse cardiac events

  30 days, 6 months, 1,2,3,4,5 years

• All-cause mortality

  30 days, 6 months, 1,2,3,4,5 years

• Cardiovascular death

  30 days, 6 months, 1,2,3,4,5 years

• Myocardial infarction

  30 days, 6 months, 1,2,3,4,5 years

• Target vessel related MI

  30 days, 6 months, 1,2,3,4,5 years

Study Arms (1)

IoNIR Ridaforolimus-Eluting Coronary Stent

EXPERIMENTAL

IoNIR Ridaforolimus-Eluting Coronary Stent System

Device: IoNIR Ridaforolimus-Eluting Coronary Stent System

Interventions

IoNIR Ridaforolimus-Eluting Coronary Stent System DEVICE

The IoNIR Ridaforolimus-Eluting Coronary Stent System is a sterile single-use device/drug combination product, comprised of a cobalt chromium (CoCr) alloybased stent coated with a bioresorbable polymer mesh which is embedded with drug, mounted on a Rapid Exchange (RX) delivery system.

IoNIR Ridaforolimus-Eluting Coronary Stent

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥18 years.
• Patient with an indication for PCI including NSTEMI (biomarkers have peaked or are falling), angina (stable or unstable), silent ischemia (in absence of symptoms a visually estimated target lesion diameter stenosis of ≥70%, a positive non-invasive stress test, or FFR ≤0.80, Pd/Pa≤0.91or iFR, RFR, DFR, DPR≤0.89 must be present).
• Non-target vessel PCIs are allowed if performed \>30 days prior to index procedure.
• Patient or legal guardian is willing and able to provide informed written consent and comply with follow-up visits and testing schedule.
• Staged procedures are allowed as long as the IoNIR stent is implanted in the last procedure and at least 30 days have elapsed between the previous procedure and the IoNIR PCI.
• A maximum of two vessels and up to two lesions may be treated (two lesions separated by up to 10mm that can be covered by a single stent are considered as one lesion).
• Lesions requiring scoring/cutting and/or rotational/orbital atherectomy and/or intra-vascular lithotripsy are allowed.
• Overlapping stents are allowed.
• Target lesion must be in a major native coronary artery with visually estimated diameter of ≥2.5 mm to ≤4.0 mm and lesion length of up to 40 mm, and appropriate size IoNIR stents are available.

You may not qualify if:

• \. ST Segment Elevation MI within past 30 days. 2. NSTEMI with biomarkers that have not peaked. 3. Significant valvular disease or planned valvular intervention. 4. PCI within the 30 days preceding the baseline procedure. 5. PCI in the target vessel within 12 months of the baseline procedure. 6. Planned staged procedures (coronary or valvular), where the study stent is implanted in the first stage.
• \. Brachytherapy in conjunction with the baseline procedure. 8. Known history of stent thrombosis. 9. Cardiogenic shock (defined as persistent hypotension (systolic blood pressure \<90 mm/Hg for more than 30 minutes) or requiring pressors or hemodynamic support, including IABP.
• \. Subject is intubated. 11. Known LVEF \<30%. 12. Contraindication to DAPT for 6 months in non-ACS patients and 12 months in ACS patients (including planned surgeries that cannot be delayed).
• \. Subject has an indication such as atrial fibrillation for oral anticoagulation/prolonged heparinization (i.e., use of coumadin/DOAC (NOAC) or prolonged enoxaparin/heparin therapy is not allowed).
• \. eGFR \<60 mL/min. 15. Hemoglobin \<10 g/dL. 16. Platelet count \<100,000 cells/mm3 or \>700,000 cells/mm3. 17. White blood cell (WBC) count \<3,000 cells/mm3. 18. Clinically significant liver disease. 19. Active peptic ulcer or active bleeding from any site. 20. Bleeding from any site within the previous 8 weeks requiring active medical or surgical attention.
• \. If femoral access is planned, significant peripheral arterial disease which precludes safe insertion of a 6F sheath.
• \. History of bleeding diathesis or coagulopathy and patients that refuse blood transfusions.
• \. Cerebrovascular accident or transient ischemic attack within the past 6 months, or any permanent neurologic defect attributed to CVA.
• \. Known allergy to the study stent components (cobalt, nickel, chromium, molybdenum, platinum, PDLG, PLC, or limus drugs (ridaforolimus, zotarolimus, tacrolimus, sirolimus, everolimus, or similar drugs or any other analogue or derivative or similar compounds).
• \. Known allergy to protocol-required concomitant medications such as aspirin, or P2Y12 inhibitors (clopidogrel, prasugrel, and ticagrelor), heparin and bivalirudin, or iodinated contrast allergy that cannot be adequately pre-medicated.
• \. Any co-morbid condition that may cause non-compliance with the protocol (e.g., dementia, substance abuse, etc.) or reduced life expectancy to \<24 months (e.g., cancer, severe heart failure, severe lung disease).
• \. Patient is participating in or plans to participate in any other investigational drug or device clinical trial that has not reached its primary endpoint.
• \. Women who are pregnant or breastfeeding. 29. Women who intend to become pregnant within 12 months after the baseline procedure (women of child-bearing potential who are sexually active must agree to use a reliable method of contraception from the time of screening through 12 months after the baseline procedure).
• \. Patient has received an organ transplant or is on a waiting list for an organ transplant.
• \. Patient is receiving or scheduled to receive chemotherapy within 30 days before or any time after the baseline procedure.

Sponsors & Collaborators

• Medinol Ltd.: lead

Study Sites (1)

St Francis Hospital Heart Center

Roslyn, New York, 11576, United States

Location

MeSH Terms

Conditions

Coronary Stenosis; Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 1, 2023
• First Posted: October 6, 2023
• Study Start: August 7, 2025
• Primary Completion: August 7, 2025
• Study Completion (Estimated): August 10, 2026
• Last Updated: September 22, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)