Bone Denisty Change in Children With Beta Thalassemia Major

NCT06069089 | Unknown

• 1 other identifier: Thalassemia major in children
• Study Type: observational
• Target: 42
• Locations: 0 countries
• Sites: N/A

Brief Summary

Bone denisty changes in children with beta thalassemia major

Conditions

Evaluate Bone Denisty Changes in Children With Beta Thalassemia Major

Outcome Measures

Primary Outcomes (1)

• Evaluate bone denisty in children with beta thalassemia major

  To evaluate bone denisty in transfusion dependent beta thalassemia major \& its relation to serum minerals \&vit D To evaluate bone denisity in transfusion dependent beta thalassemia major \& its relation to serum minerals \&vit D To evaluate bone denisity in transfusion dependent beta thalassemia major \&its relation to serrum minerals \&vitD

  One year

Study Arms (2)

Controlled beta thalassemia major

Controlled beta thalassemia major Hb\>9g/dl , serum ferritin \<500ng/ml

Radiation: Dexa scan

Uncontrolled beta thalassemia major

Uncontrolled beta thalassemia major Hb\<9g/dl , serum ferritin \>500ng/ml

Radiation: Dexa scan

Interventions

Dexa scan RADIATION

No intervention

Controlled beta thalassemia major; Uncontrolled beta thalassemia major

Eligibility Criteria

• Age: 10 Years - 18 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Children with beta thalassemia major with transfusion dependent

You may qualify if:

• \- Patient diagnosed as B thalassemia major of both sexes, age range from 10-18 year, who are poorly controlled on frequant blood transfusion. The patient who doesn't have Hb level from 9-10 g/dl, in almost always less than 9 g/dl.

You may not qualify if:

• Known metabolic bone disease. Less than 10 year or more than 18 year. Bone disease Other than hemolytic anemia.

Sponsors & Collaborators

• Marwa Hassan Abdelhamed Hassan: lead
• Assiut University: collaborator

Related Publications (1)

• Gaudio A, Morabito N, Catalano A, Rapisarda R, Xourafa A, Lasco A. Pathogenesis of Thalassemia Major-associated Osteoporosis: A Review with Insights from Clinical Experience. J Clin Res Pediatr Endocrinol. 2019 May 28;11(2):110-117. doi: 10.4274/jcrpe.galenos.2018.2018.0074. Epub 2018 Jul 11.

  PMID: 29991466 BACKGROUND

MeSH Terms

Interventions

Absorptiometry, Photon

Intervention Hierarchy (Ancestors)

Radiography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Densitometry; Photometry; Chemistry Techniques, Analytical; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assiut university , pediatrician department

Study Record Dates

• First Submitted: September 29, 2023
• First Posted: October 5, 2023
• Study Start: December 15, 2023
• Primary Completion: December 15, 2024
• Study Completion: December 31, 2024
• Last Updated: October 5, 2023

Record last verified: 2023-09