Breaks From Sedentary Behavior With Dual Tasks in Elderly

NCT06068374 | Completed DMC

• 1 other identifier: Break_Elderly
• Study Type: interventional
• Target: 27
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this project will be to compare the acute effects of breaks from sedentary behavior using dual-tasking on cerebral blood flow, vascular function, cognitive functions and blood pressure in elderly people. Participants will perform, in random order, three experimental sessions (control, break with dual-task and standard break (\[walk\]). All sessions will have a period of 4 hours in sedentary behavior. In the standard break session and in the break session with dual-task participants will take walking and dual-task breaks every 30 minutes, and in the control session they will remain seated without breaks. Before and after this period, cerebral blood flow, vascular function, cognitive functions and blood pressure will be assessed.

Conditions

Aging

Keywords

sedentary behavior; physical activity; cognitive function; vascular function

Outcome Measures

Primary Outcomes (4)

• Cerebral blood velocity [centimeters per second]

  Mean arterial velocity of middle cerebral artery will be measured using a transcranial doppler

  Before and 20 minutes after the intervention for 5 minutes

• Cognitive function - The Trail Making Tests [seconds]

  The Trail Making Tests (A and B) will be used to assess executive function and attention. Part A will determine psychomotor speed and require the participant to draw lines connecting sequentially circled numbers, such as drawing a line from 1 to 2, 2 to 3, and 3 to 4. Part B will consist of circled numbers and letters. Participants will be instructed to draw a line as quickly and as accurately as possible from 1 to A, A to 2, 2 to B, B to 3, and so on, until they complete the task. The time in seconds will be recorded in seconds after the end of each stage. After carrying out the tests, the differences between the completion times for part B - A will be calculated.

  Before and 30 minutes after the intervention

• Cognitive function - Stroop test [seconds]

  A computerized version of the Stroop test will be used in this study, using the Testinpacs® program. The tasks will be viewed on a notebook screen approximately 90 cm away from the participant. Answers to a set of tasks will be given as quickly as possible via two buttons. The cognitive portion of the Stroop test will be used as a psychometric test to assess cognition, being related to the executive functions of decision-making and inhibitory control exercised by the prefrontal cortex. The capacity for selective attention and response control will be estimated as the time difference between the third condition and the second condition. Smaller differences will indicate better selective attention and conflict resolution.

  Before and 32 minutes after the intervention

• Cognitive function - verbal fluency [number of animal names reported]

  The task will consist of recalling words that begin with the letter "F", for 60 seconds. The final score will be determined according to the number of correct words reported in 60 seconds. In the semantic modality, participants must evoke as many animals as possible in 60 seconds. The final score will be determined according to the number of animal names reported in 60 seconds.

  Before and 35 minutes after the intervention

Secondary Outcomes (4)

• Resting systolic and diastolic blood pressures [mmHg]

  Before and 10 minutes after the intervention

• Resting heart rate [bpm]

  Before and 10 minutes after the intervention

• Ambulatory systolic, diastolic, and mean blood pressures monitoring [mmHg]

  45 minutes after the intervention

• Vascular function [%]

  Before and 10 minutes after the intervention

Study Arms (3)

Break dual task

EXPERIMENTAL

Subjects will remain seated for three hours; however, every 30 minutes the subjects will be instructed to stand and take short walks with low intensity and perform a cognitive task

Other: Break of sedentary behavior with dual task

Standard break

ACTIVE COMPARATOR

Subjects will remain seated for three hours, however, every 30 minutes the subjects will be instructed to stand and take short walks at low intensity for two minutes,

Other: Break of sedentary behavior with walking

Control session

NO INTERVENTION

Subjects will remain seated for three hours

Interventions

Break of sedentary behavior with dual task OTHER

Patients will interrupt sedentary behavior performing walking and cognitive activities simultaneously

Break dual task

Break of sedentary behavior with walking OTHER

Patients will interrupt sedentary behavior performing walking

Standard break

Eligibility Criteria

• Age: 60 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• aged 60 years or over
• be physically independent based on the Katz Test
• have no history of heart attack
• not having suffered a stroke
• not have heart failure
• do not have joint problems that prevent them from carrying out experimental sessions
• do not have a history of neurodegenerative diseases
• obtain ≥ 26 points in the Montreal Cognitive Assessment (MoCA)
• are not involved in the practice of regular, systematic physical activity more than once a week over the last six months prior to the start of the study
• not be smokers and morbidly obese.

Sponsors & Collaborators

• University of Nove de Julho: lead

Study Sites (1)

Universidade Nove de Julho

São Paulo, 01504-001, Brazil

Location

MeSH Terms

Conditions

Sedentary Behavior; Motor Activity

Interventions

Walking

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Locomotion; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Exercise; Motor Activity

Study Officials

• Raphael Dias, PhD

  University of Nove de Julho

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The evaluator of flow-mediated dilation is blinded
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 22, 2023
• First Posted: October 5, 2023
• Study Start: February 27, 2023
• Primary Completion: July 31, 2024
• Study Completion: July 31, 2024
• Last Updated: December 4, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ANALYTIC CODE
• Time Frame: One year after the completion
• Access Criteria: Upon request

Locations

BR (1)