Kidney and Pregnancy Registry
1 other identifier
observational
600
1 country
1
Brief Summary
Maternal physiological adaptation to pregnancy plays an important role in the smooth progress of the pregnancy and the healthy growth of the fetus. This physiological adaptation takes place at the level of several organs, including the kidney. Physiological changes during a normal pregnancy take place at the anatomical, glomerular and tubular level. In the event of pre-existing kidney damage (glomerular and tubular diseases, stone disease, high blood pressure (hypertension) etc...) these adaptations will not be optimal. This will have implications for:
- the course of the pregnancy with the occurrence of feto-maternal complications: miscarriages, pre-eclampsia, intrauterine growth retardation (IUGR), low birth weight, prematurity. The risk of feto-maternal complications increases with the degree of renal failure or with certain pathologies such as lupus.
- progression of kidney disease Some maternal complications have long-term implications: preeclampsia is associated with a high risk of subsequent cardiovascular and renal complications. Pregnancies in these patients are high-risk pregnancies and require specialized management by an experienced group of gynecologists and nephrologists. The creation of a retrospective and prospective register by collecting demographic, clinical, biological, radiological and genetic data concerning patients at each consultation within the CHU Brugmann Hospital will allow:
- to establish the epidemiological and clinico-biological characteristics of the patients followed at the Kidney and Pregnancy Clinic at the CHU Brugmann Hospital
- to analyze the risk factors for feto-maternal complications
- to analyze the risk factors for the occurrence of subsequent cardio-renal pathologies in patients who have had preeclampsia or an event during their pregnancy
- to identify patients who will need specialized genetic testing
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2023
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 12, 2023
CompletedFirst Submitted
Initial submission to the registry
September 28, 2023
CompletedFirst Posted
Study publicly available on registry
October 5, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2043
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 1, 2043
October 5, 2023
September 1, 2023
20.2 years
September 28, 2023
September 28, 2023
Conditions
Outcome Measures
Primary Outcomes (5)
Epidemiological characteristics of patients
20 years
Clinico-biological characteristics of patients
20 years
Risk factors for feto-maternal complications
20 years
Risk factors for cardio-renal pathologies
Risk factors for the occurrence of subsequent cardio-renal pathologies in patients who had preeclampsia or an event during their pregnancy
20 years
Need for genetic testing
Identification of patients who will need specialized genetic testing
20 years
Study Arms (1)
Kidney and Pregnancy clinic consultations
Patients followed at the Kidney and Pregnancy clinic pre-conception, during pregnancy and postpartum and patients subsequently referred to nephrological follow-up
Interventions
Data extraction from medical files
Eligibility Criteria
Patients followed at the Kidney and Pregnancy clinic pre-conception, during pregnancy and postpartum and patients subsequently referred to nephrological follow-up
You may qualify if:
- Pre-conception consultations
- Woman of childbearing age with:
- Renal damage (glomerular, tubular disease, renal lithiasis, systemic disease, metabolic diseases, congenital diseases, etc.)
- Hematological disorders (sickle cell disease)
- Kidney transplantation
- High blood pressure (hypertension)
- Pre-kidney transplant assessment in progress for discussion of contraception and pregnancy after kidney transplantation
- Preeclampsia
- Multiple miscarriages
- IUGR and low birth weight in the fetus
- Family history of kidney disease
- Peri-gravid consultations
- Pregnant women with
- Pre-existing kidney damage
- De novo renal failure (IR)
- +12 more criteria
You may not qualify if:
- Male patients Menopausal patients
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
CHU Brugmann
Brussels, 1020, Belgium
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Christelle Fosso
CHU Brugmann
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 20 Years
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Head of clinical research unit
Study Record Dates
First Submitted
September 28, 2023
First Posted
October 5, 2023
Study Start
September 12, 2023
Primary Completion (Estimated)
December 1, 2043
Study Completion (Estimated)
December 1, 2043
Last Updated
October 5, 2023
Record last verified: 2023-09
Data Sharing
- IPD Sharing
- Will not share