NCT06051266

Brief Summary

The study was a prospective, multicentre, randomized parallel controlled clinical trial. Randomisation was conducted by central randomisation, with random allocation codes generated by the main central computer. Enrollment was conducted by competition between different centres. In this study, the coronal, apical and angular deviations (mean, standard deviation, median, quartiles, minimum, maximum, 95% confidence interval) of the static template and dynamic navigation group guided implant placement were calculated. The data is proposed to be analysed using a mixed linear effects model.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
58

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Apr 2023

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2023

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

September 3, 2023

Completed
19 days until next milestone

First Posted

Study publicly available on registry

September 22, 2023

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2023

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2024

Completed
Last Updated

September 22, 2023

Status Verified

August 1, 2023

Enrollment Period

9 months

First QC Date

September 3, 2023

Last Update Submit

September 20, 2023

Conditions

Outcome Measures

Primary Outcomes (1)

  • Apical deviation of implant placement (mm)

    Preoperative planning and postoperative cone-beam computed tomography (CBCT) were aligned together in the software and apical deviations(mm) of implant placement were measured to compare the results of the two groups.

    About 3 days after surgery

Secondary Outcomes (7)

  • Coronal deviation of implant placement (mm)

    About 3 days after surgery

  • Angular deviation of implant placement (°)

    About 3 days after surgery

  • Operation time

    Surgery day

  • Implant stability quotient

    Surgery day

  • visual analogue scale

    About 3 days after surgery

  • +2 more secondary outcomes

Study Arms (2)

Dynamic navigation

EXPERIMENTAL
Device: Dynamic navigation

Static template

ACTIVE COMPARATOR
Device: Static template

Interventions

Dynamic navigation eliminates the need for a laboratory fabrication process and allows for direct visualisation of the operative area during implant placement. Moreover, it can avoid interfering with water cooling. Navigation-assisted surgery makes it possible to modify the implant system, length, diameter or position in real time, both in the perioperative period and during surgery.

Dynamic navigation

In most clinical situations, a static template can be used to assist in guiding the placement of implants precisely. The static guide has some limitations in that it requires additional fabrication time, has insufficient cooling in the surgical field and is not suitable for simultaneous grafting procedures.

Static template

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • years old and above
  • American society of anesthesiologists (ASA) Levels 1 and 2
  • Satisfy any of the following requirements:
  • Edentulous maxillary patients
  • Edentulous mandibular patients
  • Terminally edentulous maxillary patients (number of remaining natural teeth in the upper jaw 1-4)
  • Terminally edentulous mandibular patients (number of remaining natural teeth in the lower jaw 1-4)
  • Full-mouth edentulous patients
  • Full-mouth terminally edentulous patients (number of remaining natural teeth in one jaw 1-4)
  • Implant-supported fixed restorations or implant-supported overdenture restorations
  • Sufficient usable bone volume at implant sites, non-implant sites (≥1.5mm of remaining bone width on the labial/buccal and palatal/lingual sides after virtual implant placement in software)
  • Mouth opening of 3 fingers or more
  • Single-jawed missing patients treated with systemic periodontal therapy

You may not qualify if:

  • Have a systemic disease that may affect prognosis (e.g. diabetic patients with glycated haemoglobin \>6.5%, patients on bisphosphonate medication, patients with auto-systemic immune diseases, etc.)
  • ASA grades 3 and 4
  • Acute inflammation in the oral cavity: including uncontrolled periodontitis (periodontal probing depth \> 4 mm) and untreated acute and chronic apical periodontitis
  • Pregnancy or breastfeeding
  • History of radiotherapy to the head and neck
  • Heavy smokers (more than 10 cigarettes per day)
  • Restricted mouth opening (less than three fingers).
  • Participation in a clinical trial with another drug or device within 30 days prior to the start of the procedure (study day 0).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Shanghai Ninth People's Hospital

Shanghai, China

RECRUITING

MeSH Terms

Conditions

Jaw, Edentulous

Condition Hierarchy (Ancestors)

Jaw DiseasesMusculoskeletal DiseasesStomatognathic DiseasesMouth, EdentulousMouth DiseasesTooth Diseases

Study Officials

  • Yiqun Wu

    Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 3, 2023

First Posted

September 22, 2023

Study Start

April 1, 2023

Primary Completion

December 31, 2023

Study Completion

December 31, 2024

Last Updated

September 22, 2023

Record last verified: 2023-08

Locations