Metabolic Syndrome and Obstructive Sleep Apnea

NCT06051097 | Completed

• 1 other identifier: MS-258-2022
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Background:Metabolic syndrome is a disorder characterized by abdominal obesity,hypertension,increased triglycerides ,decreased HDL cholesterol and increased blood glucose. Accumulating evidence strongly indicates that insulin resistance and an increased amount of abdominal fat are the pathogenic factors for the characteristics of metabolic syndrome. Studies indicate that sleep apnea may be a manifestation of the metabolic syndrome. Subjects and methods:This study was conducted in the pulmonology department at kasrelainy hospital. It included 80 patients who came to the sleep lab unit for polysomnography. Each patient was subjected to full history taking including(sex,age,smoking history,presence of diabetes or hypertension),thorough clinical examination with emphasis on waist, neck\&hip circumference and blood pressure measurements,Laboratory investigations including :Lipid profile\& Diabetic profile(HBA1C).In addition to ESS and stop bang score questionnaire.

Conditions

Sleep Apnea; Metabolic Syndrome

Outcome Measures

Primary Outcomes (1)

• Predictors of metabolic syndrome among OSA patients

  evaluation of factors related to occurrence of metabolic syndrome in OSA such as age(in years),weight in kilograms(kg) and height in meters (m) will not be measured separately but combined to assess BMI( weight in kg/ height in m2) and oxygen saturation (O2%), evaluation of polysomnographic data and laboratory tests in the form of lipid profile in (mg/dl) and HBA1C (g/dl)

  6 months

Study Arms (2)

OSA with metabolic syndrome

sleep study

Diagnostic Test: sleep study

OSA without metabolic syndrome

sleep study

Diagnostic Test: sleep study

Interventions

sleep study DIAGNOSTIC_TEST

over-night polysomnography

OSA with metabolic syndrome; OSA without metabolic syndrome

Eligibility Criteria

• Age: 22 Years - 77 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This study was conducted in the pulmonology department at kasrelainy hospital.Itincluded 80 patients who came to the sleep lab unit for polysomnography.Each patient was subjected to full history taking including(sex,age,smoking history,presence of diabetes or hypertension),thorough clinical examination with emphasis on waist, neck \& hip circumference and blood pressure measurements,Laboratory investigations including: Lipid profile\&Diabetic profile(HBA1C).In addition to ESS and stop-bang score questionnaire

You may qualify if:

• Patients fulfilled the criteria of OSA ( obstructive sleep apnea) in the form of symptoms suggestive of OSA (daytime sleepiness/daytime fatigue/headache/snoring)and with AHI ( apnea-hyponea index) ≥5.

You may not qualify if:

• Cerebro-vascular accident within the preceding 30 days.
• Patients on sedatives.
• Patients on anti-psychotics

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Kasr alainy school of medicine

Cairo, 11562, Egypt

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

blood sampling for lipid profile and HBAIC

MeSH Terms

Conditions

Sleep Apnea Syndromes; Metabolic Syndrome

Interventions

Polysomnography

Condition Hierarchy (Ancestors)

Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Monitoring, Physiologic; Diagnostic Techniques and Procedures; Diagnosis

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of pulmonology

Study Record Dates

• First Submitted: September 4, 2023
• First Posted: September 22, 2023
• Study Start: September 1, 2022
• Primary Completion: March 31, 2023
• Study Completion: May 15, 2023
• Last Updated: September 22, 2023

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)