Objective Characterizatoion of Repetitive Behaviors
Actimetric and Electrophysiological Analyses of Repetitive Behaviors (Tics and Compulsions)
2 other identifiers
interventional
50
1 country
3
Brief Summary
Introduction: Repetitive behaviors (RB) constitute a broad range of symptoms across different psychiatric/neurologic disorders. The most famous are stereotypies (found in autism), compulsions (found in obsessive-compulsive-disorder, OCD) and tics (found in Gilles de la Tourette syndrome, GTS). For some patients, it is sometime difficult to distinguish the nature of the repetitive behaviors presented, however this distinction is crucial in order to chose the appropriate treatment. Aim: In our study, the investigators will try to define electrophysiological and accelerometric marker of both OCD and tics to allow objective distinction between both tics and compulsions. Method: Subjects: Both OCD and GTS patients will be recruited, 25 patients in each group. Protocol: our study protocol will involve two step: a step in laboratory, another step at patient home.
- first step: both patients group will be recorded through a high density EEG and a portative EEG while doing a task of symptom provocation. Then they will get an anatomical MRI for source recontruction. Finally, the patients will have to mimic their symptom while wearing an accelerometer (a smartwatch).
- second step: both patient groups will be recorded at home through a portative EEG while tagging their symptom through a smartwatch (also used for accelerometry). After the recording, the patients will keep the smartwatch for 2 weeks, still tagging their sympoms (compulsions or tics).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Dec 2023
Longer than P75 for not_applicable
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 28, 2023
CompletedFirst Posted
Study publicly available on registry
September 22, 2023
CompletedStudy Start
First participant enrolled
December 28, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 27, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 27, 2027
February 12, 2026
February 1, 2026
4 years
April 28, 2023
February 10, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
modification of power (μV2) in EEG frequencies before compulsions in Obsessive-Compulsive Disorder patients
change in the power EEG frequencies in OCD patients before compulsions EEG frequencies come to 0 to 250 Hz, the power is the amplitude of oscillations
one year
modification of power (μV2) in EEG frequencies before tics in Gilles de la Tourette patients
change in the power of EEG frequencies in GTS patients before tics EEG frequencies come to 0 to 250 Hz, the power is the amplitude of oscillations
one year
Secondary Outcomes (4)
Difference in power (μV2) in EEG frequencies between obsessive-compulsive disorder patients and Gilles de la Tourette patients
One year and a half
percentage (%) of compulsions and tics detected by accelerometer
One year and a half
Correlation of EEG frequency power (arbitrary units) detected before compulsions and scores get with clinical scales (Y-BOCS)
One year and a half
Correlation between number of compulsions detected by accelerometer and Y-BOCS scores get by obsessive-compulsive patients
One year and a half
Study Arms (2)
GTS group
EXPERIMENTALThis arm will be studied to get some electrophysiological marker of tics. The patients will be their own control (periods with symptoms vs. free symptoms periods).
OCD group
EXPERIMENTALThis arm will be studied to get some electrophysiological marker of compulsions. The patients will be their own control (periods with symptoms vs. free symptoms periods).
Interventions
Eligibility Criteria
You may qualify if:
- To be more of 15 years old or less than 65 years old
- To suffer from OCD and/or GTS (depressive, anxious and attention deficit hyperactivity disorder (ADHD) comorbidities are accepted)
- To be registered to the french social security (or something equivalent)
- To give written consent to participate to the research
- To have contraception for women participants (or to not have any sexual activity)
You may not qualify if:
- Patients with any other neurological disorder than GTS
- Patients who are not able to take decisions for themselves
- Pregnant women
- Patients not allowed to get MRI due to contraindication
- Patients not speaking french
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (3)
Hôpital Albert Chenevier
Créteil, 94000, France
Hôpital Henri Mondor
Créteil, 94010, France
Hôpital Pitié Salpêtrière
Paris, 75013, France
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Luc MALLET, MD
Assistance Publique - Hôpitaux de Paris
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 28, 2023
First Posted
September 22, 2023
Study Start
December 28, 2023
Primary Completion (Estimated)
December 27, 2027
Study Completion (Estimated)
December 27, 2027
Last Updated
February 12, 2026
Record last verified: 2026-02