Effect Of Scaling and Root Planning on ALP in Saliva and GCF In Periodontitis Patients Compared With Healthy Individuals

NCT06048016 | Unknown DMC

• 1 other identifier: PER7_2_1
• Study Type: interventional
• Target: 134
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this \[interventional clinical trial\] is to test effect of scaling and root plaining on Alkaline phosphatase in Saliva and Gingival crevicular fluid in periodontitis patients compared with healthy subjects The population from periodontitis patients compared with healthy individuals It aims to answer are: • 1\_Alkaline phosphatase level in saliva and GCF. 2\_Scaling and root plaining effect on Alkaline Phosphatase level. 0 participants will be asked to maintain their oral hygiene instructions. Researchers will compare \[periodontitispatientsto healthyindividuals\] to see if \[AlkalinePhosphatase level\].

Conditions

Periodontitis; Healthy

Keywords

ALP; Scaling; GCF; Saliva; Periodontitis; Health

Outcome Measures

Primary Outcomes (1)

• Effect Of Scaling and Root Planning on Alkaline Phosphatase level in saliva and GCF

  Measuring ALP level in Saliva and Gingival crevicular before and after treatment

  1 month

Secondary Outcomes (1)

• Comparing periodontitis patients to healthy individuals

  1 month

Study Arms (1)

periodontitis patients

EXPERIMENTAL

Periodontitis Patients participate to test level of ALP in saliva and GCF.

Diagnostic Test: Scaling and Root Planning

Interventions

Scaling and Root Planning DIAGNOSTIC_TEST

Scaling and Root Planning by using ultrasonic scaler ,and Gracy currettes.

Also known as: gingival debridement

periodontitis patients

Eligibility Criteria

• Age: 15 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• periodontitis patients stage I,II,III,IV Having more than 10 remaining teeth. • Systemically free

You may not qualify if:

• infectious diseases dependent on antibiotics. .inflammatory diseases depend on analgesics. . Diabetes mellites patients . Hypertensive patients
• Thyroid disease
• Patients who had professional periodontal treatment during the last 6 months.
• Pregnancy or lactation.
• Smokers.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Zahraa Nasser

Giza, Haram, 12944, Egypt

RECRUITING

MeSH Terms

Conditions

Periodontitis

Interventions

Tooth Exfoliation

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Dental Physiological Phenomena; Digestive System and Oral Physiological Phenomena

Study Officials

• Zahraa Af Nasser

  Cairo University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Zahraa AF Nasser, Master's

CONTACT

01127670057; zahraa.a.nasser@gmail.com

Azzahraa AR Afattah, Master's

CONTACT

01159866312; azzahraa.abdelrahim@dentistry.cu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle investigator

Model Details: Group 1 : 68 Periodontitis Patients, providing scaling and root plaining . Group 2:68 healthy individuals.

Study Record Dates

• First Submitted: September 13, 2023
• First Posted: September 21, 2023
• Study Start: June 15, 2023
• Primary Completion: December 30, 2023
• Study Completion: July 10, 2024
• Last Updated: September 21, 2023

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: 1 month
• Access Criteria: Phone number Consent

Locations

EG (1)