Efficiency of Flurbiprofen 2.5% in Comparison to 98% Aloe Vera Gel as an Adjunctive Therapy to Scaling and Root Planning in the Initial Treatment of Stage III Chronic Periodontitis in Smoking Patients
Sponsor study identifier
interventional
60
1 country
1
Study Start
September 30, 2022
Actual (reported)Primary Completion
May 25, 2023
Actual (reported)Study Completion
July 19, 2023
Actual (reported)This study aims to evaluate clinically the efficacy of flurbiprofen gel in comparison to Aloe Vera gel as adjunctive to SRP in the reduction of periodontal pockets in patients with chronic periodontitis in smoking patients. All patients will receive SRP prior to treatment.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 19, 2023
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 30, 2022
Actual (reported)May 25, 2023
Actual (reported)July 19, 2023
Actual (reported)September 11, 2023
Actual (reported)September 18, 2023
Actual (reported)clinical attachment level
used to assess the loss of periodontal tissue support in periodontitis. It is the distance from the cemento-enamel junction (fixed point on the tooth) to the depth of the pocket
6 months
Probing Depth
used to detect the depth of the periodontal pocket. It is the distance from the gingival margin to the base of the pocket.
6 months
Bleeding on Probing
6 months
Plaque index
6 months
Gingival index
6 months
Following scaling and root planing, the prepared 2.5% flurbiprofen was injected subgingivally in the selected deep pocket and the same was done with a placebo on the contralateral site
Following scaling and root planing, the prepared aloe vera was injected subgingivally in the selected deep pocket and the same was done with a placebo on the contralateral site
Gel was made of 20% poloxamer and 10% ethanol as an Optimum formulation with sustained release up to 48 hours and a reasonable sol gel transition phase (adjunctive to SRP)
the Aloe vera gel employed possessed a concentration of 98% and was obtained from the reputable brand Avivir (Denmark). The remaining 2% comprised normal saline. The process of obtaining the 98% Aloe vera gel involved meticulous washing of mature Aloe Vera leaves under running water, followed by the removal of their outer skin. Subsequently, each leaf was divided into smaller pieces, from which the gel was allowed to seep out and carefully collected in a sterile container. The collected gel was then stored at 4°C until the time of its application in the study (adjunctive to SRP)
Contact the study team to confirm eligibility.
Beirut Arab University
Beirut, Lebanon
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Nayer Aboelsaad, PhD
Professor and Chairman of Periodontology department - BeirutArabU
60 participants (actual enrollment reported by the registry).
First Submitted
September 11, 2023
First Posted
September 18, 2023
Study Start
September 30, 2022
Actual (reported)Remimazolam Tosilate Sedation and Midazolam Sedation in Dental Patients
Following scaling and root planing, the prepared 2.5% flurbiprofen was injected subgingivally in the selected deep pocket while the same was done with 98% aloe vera on the contralateral site
saline
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Primary Completion
May 25, 2023
Actual (reported)Study Completion
July 19, 2023
Actual (reported)Last Updated
September 18, 2023
Record last verified: 2023-08
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