NCT06040463

Brief Summary

The goal of this randomized trial is to determine the optimal combination and sequence of three enhancements for a team-based care model for patients living with diabetes in Chicago. The study aim is to determine optimization of intervention components. Participants will be randomly assigned to diabetes self-management training or remote glucose monitoring. After 6 months, participants will be rerandomized to a subsequent study arm (including a CHW support program) depending on a tailoring variable of change in A1c. Researchers will compare the final 6 study arms to see which combination and sequence of enhancements produces the most improvement in A1c.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
270

participants targeted

Target at P75+ for not_applicable diabetes

Timeline
Completed

Started Oct 2023

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 7, 2023

Completed
8 days until next milestone

First Posted

Study publicly available on registry

September 15, 2023

Completed
1 month until next milestone

Study Start

First participant enrolled

October 23, 2023

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 31, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2025

Completed
Last Updated

December 7, 2023

Status Verified

September 1, 2023

Enrollment Period

1.4 years

First QC Date

September 7, 2023

Last Update Submit

November 30, 2023

Conditions

Keywords

implementation scienceoptimization study

Outcome Measures

Primary Outcomes (1)

  • Change in A1c

    Change in A1c from baseline to the 12-month study end point measured at the patient level. Measure will be collected every 6 months, at a minimum. The 6-month A1c will be used to determine their study condition at the rerandomization poiont.

    Baseline (time = 0); 6 months (time = 1); 12 months (time = 2)

Secondary Outcomes (3)

  • Active Usage of RGM

    Data will be exported from the Glooko application monthly for the full 18 months of the trial period.

  • DSMT Attendance

    Attendance data will be collected throughout the entire study period (18 months)

  • CHW Support Adherence

    After rerandomization period (starting at 6 months post enrollment)

Study Arms (6)

Remote Glucose Monitoring > Remote Glucose Monitoring (RGM->RGM)

EXPERIMENTAL

Participant will be randomized into the RGM study arm for the first 6 months. At the 6-month rerandomization point, if the patient is a responder (A1c improved by at least 1 percentage point), patient will remain in the RGM group.

Behavioral: Remote Glucose Monitoring (RGM)

Remote Glucose Monitoring > Remote Glucose Monitoring+Community Health Worker (RGM->RGM+CHW)

EXPERIMENTAL

Participant will be randomized into the RGM study arm for the first 6 months. At the 6-month rerandomization point, if the patient is a non-responder (A1c has not improved by at least 1 percentage point), patient will be randomized again with one arm being a continuation of RGM, with the addition of a CHW to provide tailored support.

Behavioral: Remote Glucose Monitoring (RGM)Behavioral: Community Health Worker tailored support

Remote Glucose Monitoring > Diabetes Self-Management Training (RGM->DSMT)

EXPERIMENTAL

Participant will be randomized into the RGM study arm for the first 6 months. At the 6-month rerandomization point, if the patient is a non-responder (A1c has not improved by at least 1 percentage point), patient will be randomized again with one arm being diabetes self-management training (DSMT).

Behavioral: Diabetes Self-Management Training (DSMT)Behavioral: Remote Glucose Monitoring (RGM)

Diabetes Self-Management Training > Standard of Care (DSMT->SOC)

EXPERIMENTAL

Participant will be randomized into the DSMT study arm for the first 6 months. At the 6-month rerandomization point, if the patient is a responder (A1c improved by at least 1 percentage point), patient will be directed back to standard of care.

Behavioral: Diabetes Self-Management Training (DSMT)

Diabetes Self-Management Training > Community Health Worker (DSMT->CHW)

EXPERIMENTAL

Participant will be randomized into the DSMT study arm for the first 6 months. At the 6-month rerandomization point, if the patient is a non-responder (A1c has not improved by at least 1 percentage point), patient will be randomized again with one arm being a CHW to provide tailored support.

Behavioral: Diabetes Self-Management Training (DSMT)Behavioral: Community Health Worker tailored support

Diabetes Self-Management Training > Remote Glucose Monitoring (DSMT->RGM)

EXPERIMENTAL

Participant will be randomized into the DSMT study arm for the first 6 months. At the 6-month rerandomization point, if the patient is a non-responder (A1c has not improved by at least 1 percentage point), patient will be randomized again with one arm being RGM.

Behavioral: Diabetes Self-Management Training (DSMT)Behavioral: Remote Glucose Monitoring (RGM)

Interventions

The American Diabetes Association endorses the use of small-group diabetes self-management training (DSMT), for people living with diabetes to improve lifestyle, HbA1c levels, and overall quality of life. A certified diabetes care and education specialist will teach a four-part series of one-hour sessions providing culturally competent group education and discussion for groups of 5-8 patients: Session 1 - Living with diabetes - physiology of diabetes, integrating diabetes into your daily life, long term outcomes of diabetes; Session 2 - Culturally competent food education \& portion control; Session 3 - Tips \& Tricks for dining out and special occasions; Session 4 - Advanced tools and psychosocial implications of living with diabetes. While patients will be encouraged to move through the series together as a cohort, there will be make-up sessions and flexibility to ensure high-quality participation.

Also known as: Diabetes Self-Management Education and Support (DSMES)
Diabetes Self-Management Training > Community Health Worker (DSMT->CHW)Diabetes Self-Management Training > Remote Glucose Monitoring (DSMT->RGM)Diabetes Self-Management Training > Standard of Care (DSMT->SOC)Remote Glucose Monitoring > Diabetes Self-Management Training (RGM->DSMT)

Remote Glucose Monitoring (RGM) is an automated process of transmitting glucose levels directly from a personal smartphone device to a healthcare provider using a remote data transmitter. Since 2020, Sinai has worked with Glooko Inc. to provide the RGM platform and technical assistance to patients and for Sinai providers to access data remotely. Via the app, patients can: document their glucose levels; sync data from a meter, insulin pump, pen or continuous glucose monitoring device; track their weight; log food and meals; access educational resources; track steps; and track blood pressure. Remotely uploading data provides patients with a direct line to their provider for regular feedback on progress and answers to questions between clinic visits. Patients also receive one one-hour education session on RGM and the Glooko application.

Diabetes Self-Management Training > Remote Glucose Monitoring (DSMT->RGM)Remote Glucose Monitoring > Diabetes Self-Management Training (RGM->DSMT)Remote Glucose Monitoring > Remote Glucose Monitoring (RGM->RGM)Remote Glucose Monitoring > Remote Glucose Monitoring+Community Health Worker (RGM->RGM+CHW)

CHWs are frontline public health workers who are trusted members of and/or have an unusually close understanding of the community served. The Center has two bilingual (Spanish/English) CHWs; additional bilingual CHWs will be added to the team to support the proposed study. While approaches will differ slightly depending on the patient and study condition, all patients paired with a CHW will be screened for social needs utilizing a standard social determinants of health (SDoH) screening tool, receive referrals to resources to address unmet social/health needs, and aided in navigating health and social systems.

Diabetes Self-Management Training > Community Health Worker (DSMT->CHW)Remote Glucose Monitoring > Remote Glucose Monitoring+Community Health Worker (RGM->RGM+CHW)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • A diagnosis of type 1 or type 2 diabetes
  • + years of age
  • Able to provide consent
  • Identify as African American/Black or Latinx
  • most recent HbA1c \> 7%,
  • Have a smartphone compatible with the Glooko application
  • Have completed at least one Center appointment (i.e. current patient)
  • Completed at least 3 months of their assigned study condition

You may not qualify if:

  • Already an active user of RGM
  • Actively working with a CHW
  • Diagnosis of gestational diabetes (without type 1 or type 2)
  • Has a Power of Attorney
  • Be suffering from Stage-V renal disease or undergoing dialysis.
  • Be suffering from a severe form of cardiovascular disease (NYHA Class III and IV)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Mount Sinai Hospital

Chicago, Illinois, 60608, United States

RECRUITING

Related Publications (1)

  • Jacobs J, Labellarte P, Margellos-Anast H, Garcia L, Qeadan F, Tingey B, Barnick K, Dougherty A, Wagener C. Improving Diabetes Equity and Advancing Care (IDEA) to optimize team-based care at a safety-net health system for Black and Latine patients living with diabetes: study protocol for a sequential, multiple assignment, randomized trial. Trials. 2024 Jul 24;25(1):504. doi: 10.1186/s13063-024-08346-9.

MeSH Terms

Conditions

Diabetes MellitusDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2

Interventions

Palliative Care

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesAutoimmune DiseasesImmune System Diseases

Intervention Hierarchy (Ancestors)

Patient CareTherapeuticsHealth ServicesHealth Care Facilities Workforce and Services

Central Study Contacts

Jackie Jacobs, MPH

CONTACT

Helen Margellos-Anast, MPH

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Masking Details
No masking
Purpose
TREATMENT
Intervention Model
FACTORIAL
Model Details: Sequential Multiple Assignment Randomized Trial (SMART)
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 7, 2023

First Posted

September 15, 2023

Study Start

October 23, 2023

Primary Completion

March 31, 2025

Study Completion

March 31, 2025

Last Updated

December 7, 2023

Record last verified: 2023-09

Data Sharing

IPD Sharing
Will share
Shared Documents
STUDY PROTOCOL, SAP, CSR
Time Frame
Study protocol is currently available. Remaining information will be available upon study completion.

Locations