Distinct Metastatic Phenotypes Between Early-onset and Late-onset Colorectal Cancer

NCT06040021 | Completed

• 1 other identifier: FDU-EOCRC
• Study Type: observational
• Target: 15,244
• Locations: 0 countries
• Sites: N/A

Brief Summary

The clinical and pathological features of early-onset colorectal cancer (EOCRC) differ from those of late-onset colorectal cancer (LOCRC). Our research aims to thoroughly elucidate the distinctions between them by analyzing clinical prognosis, metastatic patterns, gene expression, and genomic mutation profiles. Our deliberation will uncover latent strategies for personalized therapeutic of both EOCRC and LOCRC.

Conditions

Early-onset Colorectal Cancer; Late-onset Colorectal Cancer

Outcome Measures

Primary Outcomes (1)

• OS

  overall survival

  5 years after intervention

Study Arms (3)

EOCRC

Patients aged\<50 with colorectal cancer between 2008 and 2018 in Fudan university Shanghai cancer center.

Other: standardized treatment

IOCRC

Patients aged between 50 to 70 with colorectal cancer between 2008 and 2018 in Fudan university Shanghai cancer center.

Other: standardized treatment

LOCRC

Patients aged between≥70 with colorectal cancer between 2008 and 2018 in Fudan university Shanghai cancer center.

Other: standardized treatment

Interventions

standardized treatment OTHER

Patients enrolled in these 2 cohorts all received standardized treatment of colorectal cancer.

EOCRC; IOCRC; LOCRC

Eligibility Criteria

• Age: 16 Years - 95 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with colorectal cancer hospitalized in Fudan university Shanghai cancer center.

You may qualify if:

• The initial diagnosis of colonoscopy and pathology belongs to colorectal cancer;
• Patients should sign an informed consent form after fully understanding the purpose, procedures and potential risks of the study, indicating their voluntary participation in the research.

You may not qualify if:

• Patients with obvious local or systemic severe infection;
• Acute abdomen: intestinal obstruction, peritonitis, intestinal perforation;
• Have a systemic underlying disease that has not been controlled, or is unstable;
• Patients with poor physical fitness or serious other organic diseases who cannot tolerate anesthesia and surgery;
• Women during pregnancy, perinatal and lactation;
• Patients with severe mental disorders (such as schizophrenia, bipolar disorder, etc.) or patients who are mentally incapable or unable to understand the requirements for participation in the study.

Sponsors & Collaborators

• Fudan University: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 11, 2023
• First Posted: September 15, 2023
• Study Start: January 1, 2008
• Primary Completion: December 31, 2018
• Study Completion: June 30, 2023
• Last Updated: September 15, 2023

Record last verified: 2023-09