Safety and Pharmacokinetics of HRS-1780 in Healthy Subjects and Subjects With Impaired Renal Function

NCT06039254 | Unknown Phase 1

• 1 other identifier: HRS-1780-102
• Study Type: interventional
• Target: 27
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is a multicenter, non-randomized, open-label, parallel-controlled study. The main objective is to evaluate the safety and pharmacokinetics of HRS-1780 in subjects with mild and moderate renal impairment versus healthy subjects, and to provide a basis for dose selection of HRS-1780 in patients with chronic kidney disease.

Conditions

Chronic Kidney Disease

Outcome Measures

Primary Outcomes (3)

• Pharmacokinetics-Cmax

  Maximum observed concentration of HRS-1780

  Start of Treatment to end of study (approximately 1 week)

• Pharmacokinetics-AUC0-last

  Area under the concentration-time curve from time 0 to last time point after HRS-1780 administration

  Start of Treatment to end of study (approximately 1 week)

• Pharmacokinetics-AUC0-inf

  Area under the concentration-time curve from time 0 to infinity after HRS-1780 administration

  Start of Treatment to end of study (approximately 1 week)

Secondary Outcomes (9)

• Pharmacokinetics-Tmax

  Start of Treatment to end of study (approximately 1 week)

• Pharmacokinetics-t1/2

  Start of Treatment to end of study (approximately 1 week）

• Pharmacokinetics-CL/F

  Start of Treatment to end of study (approximately 1 week)

• Pharmacokinetics-Vz/F

  Start of Treatment to end of study (approximately 1 week)

• Pharmacokinetics-Cumulative excretion (Ae)

  Start of Treatment to end of study (approximately 1 week)

Study Arms (3)

Healthy subjects group

EXPERIMENTAL

Drug: HRS-1780

Mild renal impairment group

EXPERIMENTAL

Drug: HRS-1780

Moderate renal impairment group

EXPERIMENTAL

Drug: HRS-1780

Interventions

HRS-1780 DRUG

Single dose in each arm

Healthy subjects group; Mild renal impairment group; Moderate renal impairment group

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \- Healthy subjects：
• Able to understand the trial procedures and possible risks, volunteers to participate in the trial, willing and able to comply with all scheduled visits and study procedures, and provides written informed consent.;
• Male and female, 18 to 70 years of age, inclusive;
• Body mass index (BMI) between 18.0 and 32.0 kg/m2, inclusive;
• Normal glomerular filtration rate;
• No clinically significant abnormalities in physical examination, vital signs, laboratory tests, 12-lead ECG, etc. at the investigator's discretion;
• Men and WOCBP must agree to take highly effective contraceptive methods detailed in the protocol, have no plan to have a child from signing the consent form until at least one month after IP administration, and must not undertake for sperm/egg donation. Female participants should not be lactating.
• Renal impairment subjects：
• Able to understand the trial procedures and possible risks, volunteers to participate in the trial, willing and able to comply with all scheduled visits and study procedures, and provides written informed consent.;
• Male and female, 18 to 70 years of age, inclusive;
• Body mass index (BMI) between 18.0 and 32.0 kg/m2, inclusive;
• Glomerular filtration rate between 30 to 89 mL/min, inclusive;
• Except for renal impairment and related complications, no clinically significant abnormalities in physical examination, vital signs, laboratory tests, 12-lead ECG, etc. at the investigator's discretion;
• Men and WOCBP must agree to take highly effective contraceptive methods detailed in the protocol, have no plan to have a child from signing the consent form until at least one month after IP administration, and must not undertake for sperm/egg donation. Female participants should not be lactating.

You may not qualify if:

• \- Healthy subjects：
• Known history or suspected of being allergic to study drug or any component of it, or significant allergic reactions to other biologic products and drugs, or severe food allergies;
• Clinically significant abnormalities in 12-Lead ECG;
• Severe infections, injuries, or major surgeries as determined by the investigator within 3 months prior to screening, or plans to have surgeries during the study;
• Receipt of medical devices or another investigational drug (including placebo) within 3 months or 5 half-lives, whichever is longer prior to screening, or plans to participate in another clinical study during this study;
• Use of any prescription medicine, over-the-counter medicine, herbal remedy, or nutritional supplement within 2 weeks prior to screening;
• Consumption of more than 14 units of alcohol per week within 6 months prior to screening, or incapable to refrain from consuming alcohol during the study, or positive alcohol breath test result;
• Consumption of more than 5 cigarettes daily (or products with an equivalent amount of nicotine) within 3 months prior to screening, or use of any tobacco products 48 hours prior to dosing;
• History of illicit or prescription drug abuse or addiction in the past 5 years, or illicit or prescription drug abuse within 3 months prior to screening, or positive urine drug screen;
• Unwilling or unable to comply with the contraceptive methods detailed in this protocol;
• Positive hepatitis B virus, hepatitis B core antibody, hepatitis C virus, human immunodeficiency virus, or syphilis at screening;
• History or evidence of clinically significant disorders and deemed not suitable to participate in the study by the investigator within 6 months prior to screening;
• Inability to tolerate venipuncture blood collection;
• Any other circumstances that, in the investigator's judgment, may increase the risk to the subject, or associated with the subject's participation in and completion of the study.
• Renal impairment subjects：

Sponsors & Collaborators

• Shandong Suncadia Medicine Co., Ltd.: lead

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Yue Fei

CONTACT

0518-82342973; yue.fei@hengrui.com

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 7, 2023
• First Posted: September 15, 2023
• Study Start: September 1, 2023
• Primary Completion: November 30, 2023
• Study Completion: December 8, 2023
• Last Updated: September 15, 2023

Record last verified: 2023-08