TocilizuMab discontinuAtion in GIant Cell Arteritis

NCT06037460 | Active Not Recruiting Phase 3

• 1 other identifier: SAMSON PHRCN 2021
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Giant cell arteritis (GCA) is a large-vessel vasculitis that typically occurs in people over the age of 50. Corticosteroids (GC) are the cornerstone of treatment for GCA. French guidelines recommend starting at 0.7 or 1 mg/kg/day at diagnosis, depending on the occurence of ischemic complication(s). Then, it is recommended to gradually decrease their dose to achieve withdrawal in 12 to 24 months. Despite this treatment, 47% of patients relapse. Relapses are favored by rapid reduction of corticosteroid doses and large vessel involvement at diagnosis. Fortunately, relapses are severe in only 3.3% of cases and ischemic complications are very rare. However, this contributes to prolonging the duration of corticosteroid treatment and thus the risk of cortico-induced adverse events, which have not been significantly reduced in the last 20 years. The main risk factors for the development of steroid-related complications are advanced age and cumulative steroid dose. For this reason, the development of cortisone-sparing strategies is necessary to improve the management of patients with GCA. Thanks to major advances in the understanding of the pathophysiological mechanisms of GCA, new therapeutic targets have been discovered. For example, the efficacy of tocilizumab (TCZ), an anti-IL-6 receptor monoclonal antibody, has been demonstrated in two phase 2 trials and one phase 3 trial, leading to its approval for the management of patients requiring rapid reduction in corticosteroid doses and/or those relapsing repeatedly on prednisone \>7.5 mg/day. In recently published US guidelines, TCZ can even be used at diagnosis to reduce the need for corticosteroid therapy.5 Indeed, TCZ appears to be remarkably effective in controlling GCA activity and saves approximately 2000 mg of prednisone in cumulative dose. At present, the place of TCZ compared to methotrexate in the therapeutic strategy is still being evaluated, notably through the METOGiA study (PHRC-N 2017), which is being conducted by our team. Inclusions for METOGiA ended in March 2023 with results expected in 2025. Outside of this study, approximately 1500 patients are currently receiving TCZ treatment for GCA (data from ROCHE-CHUGAI). There is no doubt that TCZ treatment is effective and rather well tolerated in the elderly population, but it generates problems that are not solved to date:

• the cost (\~900€/month)
• the difficulty monitoring these patients because the biological markers usually used to monitor GCA (CRP, ESR, fibrinogen) can no longer be measured since TCZ blocks their production by the hepatocytes. Monitoring of disease activity therefore requires very careful clinical examination and the use of expensive imaging tests such as PET scans because GCA can be active despite normal ESR, CRP and fibrinogen levels. Some studies suggest that monitoring serum IL-6 may help identify patients with active disease, but this test is not readily available and the threshold above which relapse should be suspected is unclear because TCZ induces an increase in serum IL-6 levels by blocking IL-6 receptors, even in patients in remission.
• For the same reasons, infections are difficult to detect in patients treated with TCZ. This raises the question of how to discontinue this treatment, especially since other treatments that do not interfere with CRP, ESR, or fibrinogen measurements are being evaluated. This shows that this treatment tends to be prolonged well beyond one year when the disease is often in remission without corticosteroids. This is probably related to two factors: 1/ the fear of relapse after treatment withdrawal; 2/ the absence of a scheme for withdrawing TCZ. The risk of relapse after stopping TCZ has been reported in several studies, in particular the long-term follow-up of phase 2 and 3 trials that demonstrated the efficacy of TCZ for the treatment of GCA. Overall, regardless of the duration of TCZ treatment, the risk of relapse is approximately 40% 6 months after the last injection of TCZ, and the risk of relapse is higher if the large arteries (aorta and its branches) are involved. Thus, although the available data are limited, it appears that tapering rather than immediately stopping TCZ limits the risk of relapse after full withdrawal.

Conditions

Giant Cell Arteritis

Outcome Measures

Primary Outcomes (1)

• The relapse-free survival in both groups (immediate vs. gradual discontinuation)

  The relapse-free survival in both groups (immediate vs. gradual discontinuation) defined as the time from S0 (start of immediate/progressive discontinuation strategy) to relapse or death (any cause), whichever occurs first.

  at 26 weeks of follow-up

Secondary Outcomes (9)

• Relapse-free survival in both groups (immediate vs. gradual discontinuation)

  at 26, 52 and 78 weeks of follow-up

• Cumulative prednisone dose

  at 26, 52 and 78 weeks of follow-up

• Quality of life scores (HAQ)

  at 0, 12, 26, 52 and 78 weeks of follow-up

• FACIT-Fatigue score

  at 0, 12, 26, 52 and 78 weeks of follow-up

• Percentage of patients in remission without prednisone

  at 26, 52 and 78 weeks of follow-up

Study Arms (2)

Gradual discontinuation of TCZ

EXPERIMENTAL

Drug: Tocilizumab treatment; Other: questionnaires; Biological: Blood samples; Procedure: 18FDG PET scan

Immediate discontinuation of TCZ

ACTIVE COMPARATOR

Other: questionnaires; Biological: Blood samples; Procedure: 18FDG PET scan

Interventions

Tocilizumab treatment DRUG

* 1 injection/2 weeks from W0 to W12: W0, W2, W4, W6, W8, W10, W12 * Then 1 injection/4 weeks until W24: W16, W20, W24

Gradual discontinuation of TCZ

questionnaires OTHER

HAQ, SF-36, FACIT-Fatigue score

Gradual discontinuation of TCZ; Immediate discontinuation of TCZ

Blood samples BIOLOGICAL

Additionnal blood samples for immunomonitoring

Gradual discontinuation of TCZ; Immediate discontinuation of TCZ

18FDG PET scan PROCEDURE

PETVAS calculation (to be performed between W0 and W8) (optional).

Gradual discontinuation of TCZ; Immediate discontinuation of TCZ

Eligibility Criteria

• Age: 51 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Written consent
• Diagnosis of GCA, defined by the following criteria:
• Age ≥50 years at diagnosis
• AND History of ESR ≥50 mm/h OR CRP ≥20 mg/L (optional criterion if temporal artery biopsy (TAB) is positive).
• AND at least one of the following clinical criteria:
• At least one unequivocal sign of GCA (recent headache, scalp hyperesthesia, jaw claudication, temporal artery abnormality, visual disturbances of ischemic origin)
• Clinical sign(s) of polymyalgia rheumatica (PR)
• AND at least one of the following criteria during GCA follow-up:
• TAB consistent with the diagnosis of GCA (non-necrotizing vasculitis with a mononuclear cell-rich inflammatory infiltrate or presence of granulomas, with or without multinuclear giant cells)
• Evidence of temporal artery vasculitis by echo-Doppler of the temporal arteries (unilateral or bilateral halo sign)
• Evidence of vasculitis of at least one large vessel by imaging:
• angio-CT or angio-MRI: arterial wall thickening (≥2mm for aorta; ≥1mm for supra-aortic trunks and upper extremity arteries, ≥0.6mm for the cephalic artery, …) and/or T1-weighted contrast.
• PET: grade 2 or 3\* hypermetabolism of the wall of at least one large vessel (aorta, supra-aortic trunks, cephalic vessels, upper extremity arteries) (\*i.e., arterial SUVmax ≥ liver SUVmax)
• GCA in remission for at least 12 weeks before randomisation (remission = absence of symptoms due to GCA AND CRP ≤10 mg/L)
• TCZ treatment (IV or SC) or biosimilar initiated 12 to 36 months prior to randomization

You may not qualify if:

• Person who is not affiliated with the national health insurance system
• Person subject to a measure of legal protection (guardianship, tutorship)
• Person subject to a court order
• Patient unable to give consent
• Person who does not speak French
• Pre-menopausal women (menopause = amenorrhea of more than 12 consecutive months)
• Uncontrolled psychotic state
• History of drug or alcohol intoxication requiring hospitalization within 12 months prior to randomization
• Recent or scheduled surgery within 6 months of randomization
• History of organ or hematopoietic marrow transplantation (except corneal transplantation performed at least 12 weeks prior to randomization)
• Primary or secondary immune deficiency
• Concomitant treatment with any of the following:
• Methotrexate, leflunomide, cyclosporin A, azathioprine, mycophenolate mofetil, Janus kinase inhibitors, abatacept, secukinumab, anti-TNF-α, anakinra, ustekinumab, or any other immunosuppressive drug within 12 weeks prior to randomization
• Rituximab or other anti-CD20 agent within 1 year prior to randomization
• Cyclophosphamide in the year prior to randomization

Sponsors & Collaborators

• Centre Hospitalier Universitaire Dijon: lead

Study Sites (1)

Chu Dijon Bourgogne

Dijon, 21000, France

Location

Related Publications (1)

• Samson M, Fournel I, Bourredjem A, Cortier M, Galizzi E, Cransac A, Cladiere C, Fleck C, Brayer M, Carpentier M, Alberini JL, Devilliers H, Bonnotte B. Immediate versus gradual TocilizuMab discontinuAtion in GIant Cell Arteritis: protocol of the multicentre randomised open-label MAGICA trial. BMJ Open. 2025 Oct 9;15(10):e108115. doi: 10.1136/bmjopen-2025-108115.

  PMID: 41067765 DERIVED

MeSH Terms

Conditions

Giant Cell Arteritis

Interventions

Surveys and Questionnaires; Blood Specimen Collection

Condition Hierarchy (Ancestors)

Vasculitis, Central Nervous System; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Arteritis; Vasculitis; Skin Diseases, Vascular; Skin Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health; Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 7, 2023
• First Posted: September 14, 2023
• Study Start: May 13, 2024
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): November 1, 2028
• Last Updated: May 4, 2026

Record last verified: 2026-04

Locations

FR (1)