Financial Incentives and Recruitment to the APT Webstudy

NCT06033066 | Completed

• 1 other identifier: UP-22-01037
• Study Type: interventional
• Target: 44,844
• Locations: 1 country
• Sites: 1

Brief Summary

This single-blind, three-arm, randomized, controlled trial will assess the impact of messages and financial incentives on the enrollment of demographically diverse individuals to the Alzheimer Prevention Trials (APT) Webstudy. The APT Webstudy is a novel, online registry that employs quarterly cognitive testing using validated platforms. The APT Webstudy implements fully remote assessments, coordinated by the Alzheimer's Therapeutic Research Institute (ATRI) under USC IRB #HS-17-00746. The purpose of the current study is to test whether we can increase enrollment of diverse individuals into the registry. To do this, we will work with Contra Costa Regional Medical Center (CCRMC), the county public hospital and its affiliated health centers in Contra Costa County, California, to test whether sending messages with and without financial incentives to patients who receive primary care with the health system can increase enrollment to the APT Webstudy. The investigators hypothesize that 1) a certain small financial incentive and an award opportunity based incentive (or a drawing with a prize) will increase enrollment rates of CCHS members into the APT Webstudy relative to the control group. The investigators further hypothesize that the award opportunity incentive will increase the enrollment rate of CCRMC patients into the APT Webstudy more than a certain financial incentive with the same expected value.

Conditions

Alzheimer Disease; Dementia; Preclinical Alzheimer's Disease; Prodromal Alzheimer's Disease

Keywords

Alzheimer's; Prevention; Observational; Trial-Ready Cohort

Outcome Measures

Primary Outcomes (1)

• Enrollment status into the APT Webstudy

  APT Webstudy enrollment rate based on completion of at least one of the two APT Webstudy cognitive assessments (Cognitive Function Instrument \[CFI\] and/or Cogstate Brief Battery).

  2-weeks

Secondary Outcomes (2)

• Cost per enrollee

  annual

• Completion of cognitive assessments within the APT Webstudy

  2-weeks

Study Arms (3)

Messaging Only

ACTIVE COMPARATOR

16,000 participants will be randomized to Arm 1 where no monetary incentive is offered.

Behavioral: Message

Small Incentive

EXPERIMENTAL

16,000 participants will be randomized to Arm 2 where a small one-time monetary incentive is offered.

Behavioral: Financial Incentives

Prize Incentive

EXPERIMENTAL

16,000 participants will be randomized to Arm 3 where an opportunity based incentive (or a drawing with a prize) with a single winner will be offered.

Behavioral: Financial Incentives

Interventions

Financial Incentives BEHAVIORAL

Small financial incentive or prize incentive

Prize Incentive; Small Incentive

Message BEHAVIORAL

Message inviting participant to enroll

Messaging Only

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• To be eligible to participate in this study, an individual must meet all of the following criteria:
• Patients empaneled at Contra Costa Regional Medical Center (CCRMC), the county public hospital and its affiliated health centers.
• Age 50 or older
• Literate in either English or Spanish

You may not qualify if:

• Below age 50
• Documentation of prior dementia diagnosis

Sponsors & Collaborators

• University of Southern California: lead
• American Heart Association: collaborator
• Schaeffer Center for Health Policy & Economics: collaborator
• Alzheimer's Therapeutic Research Institute: collaborator

Study Sites (1)

Contra Costa Health Plan

Martinez, California, 94553, United States

Location

Related Publications (1)

• Jacobson M, Molina-Henry D, Chang TY, Jimenez-Maggiora GA, Pramanik R, Shah SB, Aisen PS. Financial Incentives to Increase Diversity of Older Participants in a Memory Concerns Registry: A Randomized Clinical Trial. JAMA Health Forum. 2025 Aug 1;6(8):e252273. doi: 10.1001/jamahealthforum.2025.2273.

  PMID: 40844772 DERIVED

Related Links

• APT Webstudy

MeSH Terms

Conditions

Alzheimer Disease; Dementia

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Gerontology

Study Record Dates

• First Submitted: August 9, 2023
• First Posted: September 13, 2023
• Study Start: March 1, 2024
• Primary Completion: April 30, 2024
• Study Completion: April 30, 2024
• Last Updated: June 25, 2025

Record last verified: 2023-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ANALYTIC CODE
• Time Frame: Data will be made available within 6 months of publication.
• Access Criteria: Individual data shared upon request.

Locations

US (1)