TRANSPARK_LONG: The Diagnostic Value of Early Transcranial Ultrasound in Patients With Extrapyramidal Diseases in a Swedish Population

NCT06032585 | Completed

• 1 other identifier: Dnr 2022-06697-01
• Study Type: observational
• Target: 74
• Locations: 1 country
• Sites: 1

Brief Summary

Popular science summary of the project The purpose of the study is to investigate in a Swedish population how well the investigators' previous ultrasound findings match the final diagnosis (PD, APS or ET) after a particularly long follow-up time, which greatly increases the certainty that the diagnosis does not change more and is thus correct. Furthermore, the investigators want to study whether the initial ultrasound findings have changed during the control interval and whether measurement results regarding the diameter in one of the fluid-filled rooms in the brain (third ventricle) can be correlated with the development of cognitive impairment or dementia later in the course of the disease. For this, this study have got ethical permission to go into the patients' medical records and to call a subgroup back to the clinic to be able to do a new examination and a memory test.

Conditions

Parkinsonism; Tremor; Dementia

Keywords

Transcranial ultrasound; Substantia nigra

Outcome Measures

Primary Outcomes (1)

• Correlation

  Is hyperechogenicity of substantia nigra at mesencephal plane (measured bilaterally in mm2 by transcranial b-mode sonography correlated with a high percentage of patients with classical Parkinsons Disease in contrast to atypical parkinsonism patients?

  over 7-10 yrs

Secondary Outcomes (1)

• Correlation

  7-10 (retrospective)

Study Arms (1)

Patients with parkinsonism

Parkinsonism incl. tremor, parkinsons, atypical parkinsons

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Newly diagnosted patients with parkinsonism between 2013-2017 at our centre

You may qualify if:

• Patients with parkinsonism or essential tremor who came into contact with our clinic before 2017
• Satisfactory transcranial bone window
• Previous TU (clinical indication)

You may not qualify if:

• No transcranial bone window

Sponsors & Collaborators

• Region Skane: lead

Study Sites (1)

Skåne Univ Hospital

Malmo, Skåne County, 20502, Sweden

Location

MeSH Terms

Conditions

Parkinsonian Disorders; Tremor; Dementia

Condition Hierarchy (Ancestors)

Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Dyskinesias; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 4, 2023
• First Posted: September 13, 2023
• Study Start: February 8, 2024
• Primary Completion: January 1, 2025
• Study Completion: June 1, 2025
• Last Updated: July 24, 2025

Record last verified: 2025-07

Locations

SE (1)