Mechanism for Exercise to Delay Cardiac Aging
The αKlotho Protein-mediated NLRP3/Caspase-1/GSDMD Pathway Counteracts Myocardial Stunning: a Novel Mechanism for Exercise to Delay Cardiac Aging
1 other identifier
observational
40
1 country
1
Brief Summary
The goal of this clinicaltrial is to assess and compare isokinetic performance, surface electromyography, laboratory parameters, and cardiorespiratory function both before and after engaging in vigorous intermittent lifestyle physical activity(VILPA) within a healthy population. The main question it aims to answer is: \[1\] Does VILPA yield effective outcomes? Throughout the course of the trial, participants will engage in a simulated regimen of vigorous intermittent lifestyle physical activity for a duration of 8 weeks. The efficacy of the exercise protocol will be quantified and evaluated through the utilization of a wearable device.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started May 2023
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 12, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 10, 2023
CompletedFirst Submitted
Initial submission to the registry
August 31, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2023
CompletedFirst Posted
Study publicly available on registry
September 11, 2023
CompletedSeptember 11, 2023
September 1, 2023
2 months
August 31, 2023
September 7, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Isometric Strength Test
Isokinetic muscle strength testing with the Isomed 2000
15 minutes
Surface electromyography
30 minutes
Exercise Flat Test
cardiopulmonary function
30 minutes
Secondary Outcomes (2)
Fasting glucose
5 minutes
Blood lipid
5 minutes
Study Arms (1)
intervention group
The intervention measures encompass the implementation of simulated vigorous intermittent lifestyle physical activity for all participants. The specific exercise regimen involves performing rope jumping activities three times a day, with each session aimed at surpassing the exercise threshold (not conducted in a continuous manner), where the heart rate should exceed 160 beats per minute. This routine will be undertaken five times a week, continuously for a span of 8 weeks.
Interventions
The specific exercise regimen involves performing rope jumping activities three times a day, with each session aimed at surpassing the exercise threshold (not conducted in a continuous manner), where the heart rate should exceed 160 beats per minute. This routine will be undertaken five times a week, continuously for a span of 8 weeks.
Eligibility Criteria
University students
You may qualify if:
- Healthy Adults
- No exercise habits (more than 3 months)
You may not qualify if:
- Exercising ≥ 3 times per week;
- the presence of chronic diseases, such as hypertension, hyperglycemic states, etc;
- have conducted an exercise program in the past three months.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Xiao-dong Zhuanglead
Study Sites (1)
Guangdong Pharmaceutical University
Guangzhou, Guangdong, 510006, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Lizhen Liao, PhD
Department of Health, Guangdong Pharmaceutical University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Clinical Professor
Study Record Dates
First Submitted
August 31, 2023
First Posted
September 11, 2023
Study Start
May 12, 2023
Primary Completion
July 10, 2023
Study Completion
September 1, 2023
Last Updated
September 11, 2023
Record last verified: 2023-09
Data Sharing
- IPD Sharing
- Will not share