Effectiveness of Micro Connective Tissue Graft for Treatment of Multiple Adjacent Gingival Recession Defects
Tunnel Surgery Combined With a Micro Connective Tissue Graft for the Treatment of Multiple Adjacent Gingival Recession Defects: a Multi-center Randomized Controlled Clinical Trial.
1 other identifier
interventional
30
1 country
1
Brief Summary
The objective of this project is to evaluate 1-year outcomes of treatment of MAGRD using a modified coronally advanced tunnel technique (MCAT) with either conventional CTG (control group) or micro-CTG (test group).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Mar 2025
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 3, 2023
CompletedFirst Posted
Study publicly available on registry
September 11, 2023
CompletedStudy Start
First participant enrolled
March 1, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2026
ExpectedMarch 13, 2025
March 1, 2025
10 months
September 3, 2023
March 11, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Mean mid-facial recession coverage (mRC)
Percentage of the exposed tooth root covered after surgical intervention
up to 1 year
Secondary Outcomes (5)
Complete Root Coverage (CRC)
up to 1 year
Changes of Keratinized Tissue Width (KTW)
up to 1 year
Changes of Gingival Thickness (GT)
up to 1 year
Patient Morbidity
up to 2 weeks
Patient Satisfaction
up to 1 year
Study Arms (2)
Connective Tissue Graft
ACTIVE COMPARATORA mucogingival surgery where a conventional connective tissue graft harvested from the palate is placed on a recipient site prepared for modified coronally advanced tunnel and sutured to cover multiple adjacent gingival recession defects.
Micro Connective Tissue Graft
EXPERIMENTALA mucogingival surgery where multiple micro connective tissue graft harvested from the palate are placed on a recipient site prepared for modified coronally advanced tunnel and sutured to cover multiple adjacent gingival recession defects.
Interventions
Multiple adjacent gingival recession defects will be covered by coronally advanced flap combined with a connective tissue graft harvested from the palate.
Multiple adjacent gingival recession defects will be covered by coronally advanced flap combined with multiple micro connective tissue graft harvested from the palate.
The harvested connective tissue graft is divided in multiple micro connective tissue grafts with a scalpel blade before being placed on the recipient site.
Eligibility Criteria
You may qualify if:
- age ≥18 years,
- systemically healthy,
- presenting with a minimum of 4 and a maximum of 6 adjacent RT1/RT2 recessions, located in the maxilla or mandible with an apico-coronal extension (i.e. recession depth) of ≥2 mm,
- Full-Mouth Plaque Score (FMPS) \<20%,
- Full-Mouth Bleeding Score (FMBS) \<20%.
You may not qualify if:
- pregnancy or lactation,
- tobacco smoking,
- uncontrolled medical condition,
- medication that can affect gingival conditions.
- thick phenotype,
- severe tooth malpositioning,
- uncorrected trauma from toothbrushing,
- a previous history of root coverage procedures
- the presence of furcation defects.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Confident Dubai Palm
Dubai, 0000, United Arab Emirates
Related Publications (6)
Consensus report. Mucogingival therapy. Ann Periodontol. 1996 Nov;1(1):702-6. doi: 10.1902/annals.1996.1.1.702. No abstract available.
PMID: 9118277RESULTCairo F. Periodontal plastic surgery of gingival recessions at single and multiple teeth. Periodontol 2000. 2017 Oct;75(1):296-316. doi: 10.1111/prd.12186.
PMID: 28758301RESULTTonetti MS, Jepsen S; Working Group 2 of the European Workshop on Periodontology. Clinical efficacy of periodontal plastic surgery procedures: consensus report of Group 2 of the 10th European Workshop on Periodontology. J Clin Periodontol. 2014 Apr;41 Suppl 15:S36-43. doi: 10.1111/jcpe.12219.
PMID: 24640999RESULTCairo F, Nieri M, Pagliaro U. Efficacy of periodontal plastic surgery procedures in the treatment of localized facial gingival recessions. A systematic review. J Clin Periodontol. 2014 Apr;41 Suppl 15:S44-62. doi: 10.1111/jcpe.12182.
PMID: 24641000RESULTGraziani F, Gennai S, Roldan S, Discepoli N, Buti J, Madianos P, Herrera D. Efficacy of periodontal plastic procedures in the treatment of multiple gingival recessions. J Clin Periodontol. 2014 Apr;41 Suppl 15:S63-76. doi: 10.1111/jcpe.12172.
PMID: 24641002RESULTRonco V, Dard M. A novel suturing approach for tissue displacement within minimally invasive periodontal plastic surgery. Clin Case Rep. 2016 Jul 23;4(8):831-7. doi: 10.1002/ccr3.582. eCollection 2016 Aug.
PMID: 27525096RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Jan Derks, DDS, PhD
Goteborg University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 3, 2023
First Posted
September 11, 2023
Study Start
March 1, 2025
Primary Completion
January 1, 2026
Study Completion (Estimated)
August 1, 2026
Last Updated
March 13, 2025
Record last verified: 2025-03
Data Sharing
- IPD Sharing
- Will not share