Role Of Transthoracic Ultrasound in Predicting Post-extubation Distress During Successful Weaning

NCT06030401 | Unknown

• 1 other identifier: Transthoracic US
• Study Type: observational
• Target: 51
• Locations: 0 countries
• Sites: N/A

Brief Summary

-To Assess Value of Transthoracic Ultrasound In Predicting Post-extubation Distress in Respiratory ICU Using Ultrasound Parameters As Diaphragmatic Excursion ,Diaphragmatic,Diaphragmatic Thickness Fraction,Diaphragmatic Thickness.

Conditions

Transthoracic US

Outcome Measures

Primary Outcomes (1)

• post-extubation distress

  Using Transthoracic US to measure Diaphragmatic Excursion and Diaphragmatic Thickness as Predictors of Postextubation Distress during Successful Weaning Trials.

  "through study completion, an average of 3 year".

Secondary Outcomes (1)

• Evaluation of different factors that affect weaning outcome as diaphragmatic dysfunction,ventilator associated pneumonia,electrolyte disturbances and so on.

  Doing Transthoracic US 48 hour after Starting of Mechanical Ventilation when Patient becomes Weanable during Weaning Trials,and 48 hour Postextubation Weaning and 48 hour postextubation.

Interventions

Transthoracic Ultrasound DEVICE

Sonar of The Chest

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

.Any Patient Has Successful Weaning Trial above18Years old in Respiratory ICU

You may qualify if:

• Patients above 18 yrs. old who admitted to respiratory ICU and mechanically ventilated due to chest diseases and passed weaning trials

You may not qualify if:

• Pregnancy.
• Neuromuscular disorders.
• Psychiatric instability.
• Uncontrolled cardiovascular disease.
• Tracheostomy.
• patints with failed weaning trials.
• Inability to provide informed consent.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (9)

• Frutos-Vivar F, Ferguson ND, Esteban A, Epstein SK, Arabi Y, Apezteguia C, Gonzalez M, Hill NS, Nava S, D'Empaire G, Anzueto A. Risk factors for extubation failure in patients following a successful spontaneous breathing trial. Chest. 2006 Dec;130(6):1664-71. doi: 10.1378/chest.130.6.1664.

  PMID: 17166980 BACKGROUND

• Lichtenstein DA. Point-of-care ultrasound: Infection control in the intensive care unit. Crit Care Med. 2007 May;35(5 Suppl):S262-7. doi: 10.1097/01.CCM.0000260675.45549.12.

  PMID: 17446786 RESULT

• Volpicelli G, Elbarbary M, Blaivas M, Lichtenstein DA, Mathis G, Kirkpatrick AW, Melniker L, Gargani L, Noble VE, Via G, Dean A, Tsung JW, Soldati G, Copetti R, Bouhemad B, Reissig A, Agricola E, Rouby JJ, Arbelot C, Liteplo A, Sargsyan A, Silva F, Hoppmann R, Breitkreutz R, Seibel A, Neri L, Storti E, Petrovic T; International Liaison Committee on Lung Ultrasound (ILC-LUS) for International Consensus Conference on Lung Ultrasound (ICC-LUS). International evidence-based recommendations for point-of-care lung ultrasound. Intensive Care Med. 2012 Apr;38(4):577-91. doi: 10.1007/s00134-012-2513-4. Epub 2012 Mar 6.

  PMID: 22392031 RESULT

• Boussuges A, Gole Y, Blanc P. Diaphragmatic motion studied by m-mode ultrasonography: methods, reproducibility, and normal values. Chest. 2009 Feb;135(2):391-400. doi: 10.1378/chest.08-1541. Epub 2008 Nov 18.

  PMID: 19017880 RESULT

• Vivier E, Mekontso Dessap A, Dimassi S, Vargas F, Lyazidi A, Thille AW, Brochard L. Diaphragm ultrasonography to estimate the work of breathing during non-invasive ventilation. Intensive Care Med. 2012 May;38(5):796-803. doi: 10.1007/s00134-012-2547-7. Epub 2012 Apr 5.

  PMID: 22476448 RESULT

• McConville JF, Kress JP. Weaning patients from the ventilator. N Engl J Med. 2013 Mar 14;368(11):1068-9. doi: 10.1056/NEJMc1300398. No abstract available.

  PMID: 23484845 RESULT

• Epstein SK, Nevins ML, Chung J. Effect of unplanned extubation on outcome of mechanical ventilation. Am J Respir Crit Care Med. 2000 Jun;161(6):1912-6. doi: 10.1164/ajrccm.161.6.9908068.

  PMID: 10852766 RESULT

• Shen HN, Lin LY, Chen KY, Kuo PH, Yu CJ, Wu HD, Yang PC. Changes of heart rate variability during ventilator weaning. Chest. 2003 Apr;123(4):1222-8. doi: 10.1378/chest.123.4.1222.

  PMID: 12684315 RESULT

• Ueki J, De Bruin PF, Pride NB. In vivo assessment of diaphragm contraction by ultrasound in normal subjects. Thorax. 1995 Nov;50(11):1157-61. doi: 10.1136/thx.50.11.1157.

  PMID: 8553271 RESULT

Study Officials

• Hoda Ahmad Ali, prof

  Respiratory ICU of Assiut University Hospital

  STUDY DIRECTOR

• Ali Abdelazeem Hassan, prof

  Respiratory ICU of Assiut University Hospital

  STUDY DIRECTOR

Central Study Contacts

Rehab Haredy Hassan, Resident Physicion

CONTACT

01026128677; rehabharedy@gmail.com

Maha kamel Ghanem, prof

CONTACT

01227694434; mahaghanem@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident physicion

Study Record Dates

• First Submitted: August 9, 2023
• First Posted: September 11, 2023
• Study Start: September 1, 2023
• Primary Completion: September 1, 2025
• Study Completion: December 1, 2025
• Last Updated: September 11, 2023

Record last verified: 2023-09