tACS for Sensory Motor Recovery After Stroke
tACS Brain Neuromodulation for Sensory and Motor Recovery After Neurological Impairments
1 other identifier
interventional
14
1 country
1
Brief Summary
The overall goal is to investigate the effectiveness of a novel intervention - transcranial alternating current stimulation (tACS) for motor recovery in stroke survivors.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Sep 2025
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 10, 2023
CompletedFirst Posted
Study publicly available on registry
September 8, 2023
CompletedStudy Start
First participant enrolled
September 1, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
March 31, 2028
February 24, 2025
February 1, 2025
2.1 years
May 10, 2023
February 20, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Block and Box Test (BBT) of Motor functional test
The Box and Block Test (BBT) measures unilateral gross manual dexterity. It is a quick and simple test used with a wide range of populations, including clients with stroke.
Change of BBT performance 5 minutes before and 5 minutes after the tACS intervention will be measured.
EEG alpha band and Beta band
Electroencephalography (EEG) is valuable to infer and evaluate the neural interaction. Components of the alpha and beta frequency bands like the sensorimotor rhythm originated from the primary motor cortex and related brain areas reflect human movement. The power of 8-13 Hz alpha and 14-30 Hz beta frequency bands will be used for the classification.
Change of EEG alpha band and Beta band 5 minutes before and 5 minutes after the tACS intervention will be measured.
Study Arms (3)
tACS Sham, tACS 10Hz, tACS 20Hz
EXPERIMENTALtACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns.
HD-tACS 20Hz, HD-tACS 10Hz, HD-tACS Sham
EXPERIMENTALtACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns.
HD-tACS 10Hz, HD-tACS 20Hz, HD-tACS Sham
EXPERIMENTALtACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns.
Interventions
Sham tACS will applied to the brain through the scalp for 20 minutes.
10Hz tACS will applied to the brain through the scalp for 20 minutes.
20Hz tACS will applied to the brain through the scalp for 20 minutes.
Eligibility Criteria
You may not qualify if:
- Age between 18\~75 years old
- ≥ 6 months post stroke, medically stable;
- Unilateral, single stroke (no restriction on type (ischemic or hemorrhagic) or volume (large or small) of stroke);
- Visible finger flexor activation/movement
- The ability to give consent
- Patients with visual deficit/neglect; hearing or cognitive impairment;
- Patients that are currently adjusting tone alternating medications (e.g., baclofen), or
- Patients received botulinum toxin injection to the arm/fingers \<4 months, or phenol injections \<2 years;
- Patients with pacemaker, metal implants or supplemental oxygen;
- Patients who have musculoskeletal disorders, including pain in the affected side
- Women who are pregnant.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
The University of Texas Health Science Center
Houston, Texas, 77030, United States
Study Officials
- PRINCIPAL INVESTIGATOR
Sheng Li, MD, Ph.D
The University of Texas Health Science Center, Houston
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
May 10, 2023
First Posted
September 8, 2023
Study Start
September 1, 2025
Primary Completion (Estimated)
September 30, 2027
Study Completion (Estimated)
March 31, 2028
Last Updated
February 24, 2025
Record last verified: 2025-02
Data Sharing
- IPD Sharing
- Will not share