Evaluation of Socket Preservation Using Autogenous Dentine Graft With Or Without Autologous Fibrin Glue

NCT06027528 | Completed

• 1 other identifier: 22623
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

• The aim of this interventional study is to investigate the dimensional changes in buccolingual alveolar ridge width in socket preservation using sticky dentin vs dentin graft alone
• The main question: is dentin graft mixed with autologous fibrin glue has better dimensional changes than using dentin graft alone ?
• outcomes: Change in buccolingual alveolar ridge width as well as apico-coronal alveolar ridge height

Conditions

Unrestorable Dentition

Keywords

socket preservation; alveolar ridge preservation; dentin graft; autologous fibrin glue; sticky dentin; sticky graft

Outcome Measures

Primary Outcomes (1)

• Change in buccolingual alveolar ridge width dimensions immediately after tooth extraction (baseline) and ≥ 6 months after (follow-up).

  superimposition of the 2 CBCT and using Scans which will be exported as DICOM format to 3D viewer software

  6 month

Secondary Outcomes (1)

• changes in apico-coronal alveolar ridge height immediately after tooth extraction and 6 months after

  6 months

Study Arms (2)

dentin graft mixed with autologous fibrin glue

EXPERIMENTAL

extracted tooth will be grinded into small particles to form dentin graft that will be mixed with autologous fibrin glue to be grafted in the extracted socket

Procedure: dentin graft mixed with autologous fibrin glue

dentin graft

ACTIVE COMPARATOR

extracted tooth will be grafted in the extracted socket

Procedure: dentin graft

Interventions

dentin graft mixed with autologous fibrin glue PROCEDURE

extracted tooth will be grinded into small particles to form dentin graft that will be mixed with autologous fibrin glue to be grafted in the extracted socket using centrifuge

dentin graft mixed with autologous fibrin glue

dentin graft PROCEDURE

extracted tooth will be grafted in the socket

dentin graft

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Systemically healthy patients ≥18 years old
• Nonsmoker
• Teeth with root fracture, teeth with failed endodontic therapy or advanced caries
• Intact extraction socket with no dehiscence or fenestration.

You may not qualify if:

• Patients with systemic diseases.
• Patients with dehiscence or fenestrations
• Patients with presence or history of osteonecrosis of the jaws, with use of bisphosphonates, exposure to head and neck radiation, chemotherapy.
• Patients with large distinct pre-apical pathology
• Smokers of more than 10 cigarettes a day or equivalent to cigarettes
• Breastfeeding or pregnant women
• Patients without availability to attend follow-up visits or patients rejecting to sign the informed consent.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo University

Cairo, 12012, Egypt

Location

Study Officials

• Amr Zahran, Professor

  Cairo University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Teaching assistant in periodontology department

Study Record Dates

• First Submitted: August 31, 2023
• First Posted: September 7, 2023
• Study Start: September 1, 2023
• Primary Completion: March 21, 2024
• Study Completion: August 31, 2025
• Last Updated: April 9, 2026

Record last verified: 2026-04

Locations

EG (1)