NCT06025565

Brief Summary

The study will address the gaps in the pain experience measurement in those with lateral elbow tendinopathy (LET) by building on the current body of literature, as well as applying modern pain science measures. The comprehensive measurement of various biomedical, psychological, and psychosocial constructs will provide pain profiles that will allow for the subclassification of LET to better inform loading prescriptions based on the systemic effects from LET.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
70

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Aug 2023

Geographic Reach
1 country

16 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 18, 2023

Completed
Same day until next milestone

Study Start

First participant enrolled

August 18, 2023

Completed
19 days until next milestone

First Posted

Study publicly available on registry

September 6, 2023

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 14, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 14, 2025

Completed
Last Updated

July 2, 2025

Status Verified

June 1, 2025

Enrollment Period

1.8 years

First QC Date

August 18, 2023

Last Update Submit

June 27, 2025

Conditions

Keywords

Pain

Outcome Measures

Primary Outcomes (7)

  • Short Form-McGill Pain Questionnaire-2

    1. The subject will be asked to rate their pain on a 0-10 scale for 22 different pain descriptors. 2. Continuous (1, 5, 6, 8, 9, 10), Intermittent (2, 3, 4, 11, 16, 18), Neuropathic (7, 17, 19, 20, 21, 22), and Affective (12, 13, 14, 15) subscales will be calculated by taking the mean of these items scores in addition to total score. 3. The subject will also mark their pain on a numeric pain rating score. 4. Scale is 0-10. 5. Higher score is worse.

    Baseline

  • Patient Specific Functional Scale

    1. The subject will identify 3 activities that are most limited and meaningful to them. 2. The subject will rate these activities on an 11-point scale ranging from 0 "unable to perform" to 10 "Able to perform the activity at the same level as before the injury or problem." 3. Scale is 0-30. 4. Higher score is better.

    Baseline

  • Central Sensitization Inventory

    1. The subject will be asked to assess for the presence of a central sensitization state on 25 questions scored in ordinal fashion 0 (never) - 4 (always). 2. Data from this instrument will be obtained by recording the total score on a scale of 0-100. 3. Higher score is worse.

    Baseline

  • Multidimensional health locus of control scale form C

    1. The subject rates their opinion or sense that his/her outcomes are determined by luck, fate, or a random occurrence that controls experiences. 2. The 6-point Likert scale is rated from strongly agree to strongly disagree, with 18 questions with 3 subscales including different types of loci of control (LOC; internal, chance, and doctors). 3. Chance LOC scores range from 6-36 in an ordinal measurement. 4. Data from this instrument will be obtained by recording the total score on a scale of 6-36. 5. Higher score is worse.

    Baseline

  • Pain Catastrophizing Scale

    1. The subject will be asked to assess for the presence of a pain catastrophizing on 13 questions scored in ordinal fashion 0 (not at all) - 4 (all the time). 2. Data from this instrument will be obtained by recording the total score on a scale of 0-52. 3. Higher score is worse.

    Baseline

  • Fear Avoidance Belief Questionnaire

    1. The subject will be asked to assess for the presence of fear avoidance behavior. 2. Items are scored on a 6-point Likert scale with questions 2-5 a subscale for work and 6, 7, 9, 10, 11, 12, and 15 for physical activity. 3. Scale is 0-66. 4. Higher score is worse.

    Baseline

  • Hospital Anxiety and Depression Scale

    1. The subject will be asked to assess for the presence of anxiety or depression on 14 questions scored in 4-point Likert scale. 2. Data from this instrument will be obtained by recording the total score and subscores for anxiety and depression. 3. Scale is 0-56 4. Higher score is worse.

    Baseline

Secondary Outcomes (4)

  • Pressure Pain Threshold

    Baseline

  • Two Point Discrimination

    Baseline

  • Laterality

    Baseline

  • Pain-Free Grip Strength

    Baseline

Study Arms (1)

LET

Patients with tennis elbow.

Diagnostic Test: Pain Experience Measures

Interventions

Patient reported outcomes measures, quantitative sensory testing, and physical examination measures.

LET

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Outpatient orthopedic clinics and those located throughout the Philadelphia region.

You may qualify if:

  • English speaking and reading
  • Aged 18-75
  • Diagnosis of lateral elbow tendinopathy provoked by 2 clinical tests: painful resisted 2nd or 3rd finger extension, painful wrist extension, painful stretching of forearm extensor muscles, or painful gripping.

You may not qualify if:

  • Receiving any medical intervention for LET from a physician within 90 days. Medical intervention operationally defined as any intervention requiring a medical state license to administer (injection or surgery) or prescribe (medication applied to or ingested that is not available without a physician script) with the exception of patient education.
  • Positive mechanical sensitivity of the median nerve (Upper Limb Tension Test a (ULTTa)).
  • Positive pain provocation of passive elbow flexion.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (16)

Philadelphia Hand to Shoulder Clinic

Cape May, New Jersey, 08210, United States

Location

Philadelphia Hand to Shoulder Center

Cherry Hill, New Jersey, 08003, United States

Location

Philadelphia Hand to Shoulder Center

Collegeville, Pennsylvania, 19426, United States

Location

Jefferson Rehabilitation

Fairless Hills, Pennsylvania, 19030, United States

Location

Philadelphia Hand to Shoulder Center

Glen Mills, Pennsylvania, 19342, United States

Location

Philadelphia Hand to Shoulder Center

King of Prussia, Pennsylvania, 19406, United States

Location

Philadelphia Hand to Shoulder Center

Langhorne, Pennsylvania, 19047, United States

Location

Philadelphia Hand to Shoulder Center

Lansdale, Pennsylvania, 19446, United States

Location

Thomas Jefferson University

Philadelphia, Pennsylvania, 19107-5084, United States

Location

Philadelphia Hand to Shoulder Clinic

Philadelphia, Pennsylvania, 19112, United States

Location

Jefferson Rehabilitation

Philadelphia, Pennsylvania, 19130, United States

Location

Philadelphia Hand to Shoulder Center

Rockledge, Pennsylvania, 19046, United States

Location

Jefferson Rehabilitation

Torresdale, Pennsylvania, 19114, United States

Location

Jefferson Rehabilitation

Warminster, Pennsylvania, 18974, United States

Location

Jefferson Rehabilitation

Willow Grove, Pennsylvania, 19090, United States

Location

Philadelphia Hand to Shoulder Center

Willow Grove, Pennsylvania, 19090, United States

Location

MeSH Terms

Conditions

Elbow TendinopathyTendinopathyTennis ElbowPain

Condition Hierarchy (Ancestors)

Muscular DiseasesMusculoskeletal DiseasesElbow InjuriesArm InjuriesWounds and InjuriesTendon InjuriesNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 18, 2023

First Posted

September 6, 2023

Study Start

August 18, 2023

Primary Completion

June 14, 2025

Study Completion

June 14, 2025

Last Updated

July 2, 2025

Record last verified: 2025-06

Locations