CBCT Analysis of the Craniofacial Architecture in Young, Non-overweight Apneic Adult Phenotype

NCT06022679 | Completed

• 2 other identifiers: B70720220000102022/72
• Study Type: observational
• Target: 46
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective, controlled study will compare the 3D cephalometric analysis of bone and craniofacial soft tissues in young (18-35 years) non-overweight apneic adults phenotype between a test group (with AHI 15) and a control group (healthy subjects with AHI \< 15).

Conditions

OSA

Keywords

Young no-overweight adult; OSA; cephalometry; 3D

Outcome Measures

Primary Outcomes (1)

• maxillary volume

  maxillary volume with 3D cephalométric analysis

  2month

Study Arms (2)

Test group SAHOS

The test group consisted of 23 patients ( 9 girls and 14 boys) recruited on the basis of polysomnography at sleep center of CHU Liege for suspected sleep disorders between 1 january 2022 and 1 april 2023, with IAH \>15

Other: CBCT

Control group no SAHOS

Concerning the control group, the participants, adults volunteers are recruited among friends and families of students who collaborate with sleep center for scientific projects. These subjects have no complaints related to OSA and will have to undergo a sleep examination (ventilatory polygraphy) to certify the absence of OSA. This group consisted of 23 patients (14 girls and 9 boys).

Other: CBCT

Interventions

CBCT OTHER

CBCT examination in supine position A computerized 3D-analysis using Dolphin Imaging 11.95 software was performed in each CBCT.

Control group no SAHOS; Test group SAHOS

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Young people (18-35 years) non-overweight apneic divided into 2 groups: a test group (with AHI 15) and a control group (healthy subjects with AHI \< 15).

You may qualify if:

• (1) patients aged between 18 and 35 years ;
• (2) Body Mass Index (BMI) lower than 30kg/m² ;
• (3) alcohol consumption less than 4 unit per day ;
• (4) tabacco use less than 6 cigarettes per day ;
• (5) no illicit drug use ; and
• (6) absence of chronic pathology or medication.

You may not qualify if:

• (1) presence of an acute illness on the day of admission ;
• (2) patients treated with orthognathic surgery after apnea screening ;
• (3) patients with polysomnography with a sleep treatment device (PPCN or Mandibular advancement device).

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Liege: lead

Study Sites (1)

CHU Liège, site Brull

Liège, 4020, Belgium

Location

Related Publications (1)

• Jadoul M, Albert A, Maes N, Poirrier R, Poirrier AL, Bruwier A. Three-dimensional cone beam computed tomography analysis of craniofacial phenotype in nonobese apneic young adults. Laryngoscope Investig Otolaryngol. 2025 Jan 31;10(1):e70061. doi: 10.1002/lio2.70061. eCollection 2025 Feb.

  PMID: 39897118 DERIVED

Study Officials

• Annick AB Bruwier

  Service d'orthopédie dento-faciale CHU Liège

  STUDY DIRECTOR

• mathilde jadoul

  Service Orthopédie dento-faciale CHU Liege

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: post graduated dento facial orthopedic department

Study Record Dates

• First Submitted: August 16, 2023
• First Posted: September 5, 2023
• Study Start: April 1, 2022
• Primary Completion: April 1, 2023
• Study Completion: April 1, 2023
• Last Updated: September 5, 2023

Record last verified: 2023-08

Locations

BE (1)