What To-be-discard Biomaterials From ART Cycles Can Tell us About the Treatment Cycle Outcome?

NCT06021340 | Recruiting

• 1 other identifier: 2023.066
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Various to-be-discard material from IVF treatment cycle will be collect and examined, aiming to identify potential reasons of successful outcome or cycle failure.

Conditions

IVF; Infertility

Outcome Measures

Primary Outcomes (2)

• DNA/RNA sequencing data

  DNA / RNA analysis including the length and the quantity, RNA-seq will be applied for transcriptome profiling. Next generation sequencing will be performed to determine the sequence of DNA/RNA for our collected samples.

  Through study completion, around 3 year

• Proteomic profile

  Protein profile will be investigated in a pool sample, treated samples will go for mass spectrometry (MS) data acquisition and finally destined for data analysis and interpretation.

  Through study completion, around 3 year

Secondary Outcomes (3)

• Blastocyst formation rate

  5 days after fertilization

• Clinical pregnancy rate

  Around 5 weeks after embryo transfer

• Live birth rate

  Around 9 months after embryo transfer

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Study population will include patients attending the Assisted Reproductive Technolohy (ART) Unit of the Chinese University of Hong Kong for ART treatment.

You may qualify if:

• Patients attending the Assisted Reproductive Technology (ART) Unit of the Chinese University of Hong Kong for ART treatment.
• Participant able to give voluntary, written, informed consent to participate in the study.

You may not qualify if:

• Patient using donor gamete in IVF treatment
• Patient refuses to join and failed to giving consent for any reasons

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

The Chinese University of Hong Kong and Prince of Wales Hospital

Hong Kong, Hong Kong

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

IVF cycle to-be-discard biomaterials including follicular fluid, seminal plasma, immature oocytes, abnormal fertilized zygote, unfertilized zygote, arrested embryos, poor quality blastocysts, spent culture medium.

MeSH Terms

Conditions

Infertility

Condition Hierarchy (Ancestors)

Genital Diseases; Urogenital Diseases

Study Officials

• Yiu Leung D Chan, DPhil

  CUHK

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yiu Leung D Chan, DPhil

CONTACT

(852) 3505 3199; drdcyl16@cuhk.edu.hk

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assited Professor

Study Record Dates

• First Submitted: August 23, 2023
• First Posted: September 1, 2023
• Study Start: July 4, 2023
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): June 1, 2027
• Last Updated: September 1, 2023

Record last verified: 2023-08

Locations

HK (1)