"Can Do" Versus "Do Do" in Patients With Breast Cancer

NCT06018051 | Completed

• 1 other identifier: GO 23/582
• Study Type: observational
• Target: 59
• Locations: 1 country
• Sites: 1

Brief Summary

Breast cancer occurs as a result of uncontrolled proliferation of cells in the breast tissue. Breast cancer is the most common type of cancer among women worldwide and is an important problem that threatens women's lives. The incidence rate has reached approximately 16 Breast cancer treatment consists of local and systemic therapies. While local treatments include surgery and radiotherapy, systemic treatments, which are administered in two different ways, namely adjuvant and neoadjuvant systemic treatments, consist of chemotherapy, hormone therapy and targeted biological therapies. Although the treatment options for breast cancer are increasing day by day, there are many complications during and after treatment. These complications negatively affect functionality and quality of life The 6-minute walk test (6MWD) is a widely used test for indirect measurement of cardiorespiratory fitness in various cancer populations. Studies have proven that the 6MWT is safe and feasible in breast cancer patients. The concept of 'can do, do do' has recently emerged to describe impaired physical functions in chronic obstructive pulmonary disease (COPD) and asthma. This concept categorizes participants into four quadrants based on physical activity level and functional capacity measurements and cut-off point. This concept has proven useful for measuring physical function in both asthma and COPD. This concept may be useful in understanding physical functioning in breast cancer patients. Therefore, The aim of this study is to apply the concept of 'can do, do do' in breast cancer patients, to determine the quadrants according to physical activity level and functional capacity measurements in breast cancer patients, to investigate whether and to what extent there is a difference, whether and to what extent there is a difference between demographic information, disease stages, comorbidity level, clinical features, peripheral muscle strength, fatigue and quality of life and upper extremity functionality according to quadrants.

Conditions

Breast Cancer; Exercise Capacity; Physical Activity

Keywords

breast cancer; Quality of life.; exercise; physical activity; Physical capacity

Outcome Measures

Primary Outcomes (2)

• Functional Exercise Capacity

  Six-minute walk test (6MWT)

  One Year

• Physical Activity Level

  SenseWear Armband (SWA)

  One Year

Secondary Outcomes (5)

• Comorbidity Assessment

  One Year

• Peripheral muscle strength assessment

  One Year

• Evaluation of Upper Extremity Functionality

  One Year

• Fatigue Assessment

  One Year

• Evaluation of Quality of Life

  One Year

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients between the ages of 18-65 who were diagnosed with breast cancer in Hacettepe University Hospital, Department of Internal Medicine, Department of Medical Oncology and volunteered to participate in the study will be included in the study.

You may qualify if:

• Being between 18-65 years of age,
• Volunteering to participate in the research,
• At least 15 months after breast cancer surgery,
• Six months after active breast cancer treatment (i.e. surgery/chemotherapy),
• No problems in reading and/or understanding the scales and being able to cooperate with the tests,

You may not qualify if:

• Presence of active infection,
• Musculoskeletal and neurological diseases that may affect exercise performance, symptomatic heart disease,
• Have a neurological disease or other clinical diagnosis that may affect cognitive status.
• Musculoskeletal and neurologic disease, symptomatic heart disease, previous lung surgery and malignant disease that may affect exercise performance.
• Presence of unstable hypertension or diabetes mellitus

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Ebru Çalık Kutukcu

Ankara, Hacettepe Unıversity, 06100, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Breast Neoplasms; Motor Activity

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Behavior

Study Officials

• Ebru Calik-Kutukcu, PhD

  Hacettepe University

  PRINCIPAL INVESTIGATOR

• Melda Saglam, PhD

  Hacettepe University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: August 24, 2023
• First Posted: August 30, 2023
• Study Start: June 15, 2024
• Primary Completion: June 12, 2025
• Study Completion: June 12, 2025
• Last Updated: July 8, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)