COPD Case Finding In Nottingham and District: C-FIND COPD A Pilot Study

NCT06008145 | Active Not Recruiting

• 1 other identifier: 23RM005
• Study Type: observational
• Target: 568
• Locations: 1 country
• Sites: 1

Brief Summary

The Targeted Lung Health Check (TLHC) is currently being rolled out in many regions of the United Kingdom and has just started in Nottingham. The same cohort of people are also at high risk for Chronic Obstructive Pulmonary Disease (COPD), a lung condition often caused by smoking and leading to breathlessness and cough. This study aims to provide pilot evidence of the role of breathing tests in those who have had a Computerised Tomography (CT) scan, in order to early diagnose COPD. Currently, at diagnosis, many patients have lost 30-40% of lung function already, which is not reversible. This study will use the Nottingham University Hospitals Trust Mobile Research Unit. The unit will follow the CT scanner route 2-3 weeks later, and people who have had a CT scan will be invited for breathing tests. Participants will also collect further information on potential treatment options for people diagnosed with COPD earlier -including smoking cessation, symptom management and general health advice (vaccinations, diet, activity and managing infections). There is also an optional blood test. The study aims are to determine the uptake and acceptability of breathing tests in patients at high risk of COPD, and if a community based approach co-locating with TLHC can increase uptake. A qualitative sub-study has been added to assess the opportunities or barriers for people being invited for a COPD diagnosis visit in the community. This sub-study will have a recruitment target of 20 participants. It will involve transcribed interviews. This will help determine the accessibility of the mobile research unit in use for this study.

Conditions

COPD

Keywords

COPD

Outcome Measures

Primary Outcomes (1)

• Proportion of people who take up the invite to attend for a C-FIND visit.

  0-100%

  1.5 years

Secondary Outcomes (17)

• Proportion diagnosed with COPD

  1.5 years

• CAT COPD Quality of Life Score

  1 day

• MRC breathlessness score

  1 day

• Exacerbation Frequency

  1 day

• EQ-5D-5L - Health Status

  1 day

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The Targeted Lung Health Check (THLC) cohort are a population that are at high risk for COPD, a lung condition often caused by smoking. This same population will be invited to undertake breathing test in order to early diagnose COPD.

You may qualify if:

• Smoking history - either compatible with TLHC (current or ex-smoker who are high risk based on lung cancer risk scores) or if self-presenting \>10 pack years (current or ex)
• Able to provide full informed consent.

You may not qualify if:

• People currently undergoing active investigation or treatment for cancer
• Unable to provide informed consent

Sponsors & Collaborators

• University of Nottingham: collaborator
• Nottingham University Hospitals NHS Trust: lead

Study Sites (1)

Nottingham University Hospitals NHS Trust

Nottingham, Nottinghamshire, NG5 1PB, United Kingdom

Location

Biospecimen

Retention: SAMPLES WITH DNA

whole blood and nasal brush

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Charlotte Bolton, MD, PhD

  Nottingham University Hospitals NHS Trust

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 20, 2023
• First Posted: August 23, 2023
• Study Start: September 21, 2023
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: December 19, 2025

Record last verified: 2025-12

Locations

GB (1)