Optimizing Postoperative Pain Control After Laparoscopic Colorectal Surgery
1 other identifier
interventional
120
1 country
1
Brief Summary
Erector spinae plane block (ESPB) is a novel regional block technique that was proven to have superior outcomes in relieving postoperative pain in colorectal surgeries.Ketamine enhances the impact of local anaesthetics by reducing the duration and extent of motor block while shortening the onset of sensory and motor block.Transdermal Fentanyl Patch (TFP) was better than transdermal buprenorphine in postoperative analgesia following abdominal surgeries.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable postoperative-pain
Started Sep 2023
Typical duration for not_applicable postoperative-pain
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 17, 2023
CompletedFirst Posted
Study publicly available on registry
August 23, 2023
CompletedStudy Start
First participant enrolled
September 5, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 22, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
July 22, 2025
CompletedFebruary 18, 2026
February 1, 2026
1.9 years
August 17, 2023
February 16, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
The time to first rescue analgesia after surgery (hour)
The time to first rescue analgesia after surgery (hour)
The first 48 hours after surgery
Study Arms (3)
Bupivacaine and ketamine
OTHERBupivacaine and transdermal fentanyl patch
OTHERBupivacaine
OTHERInterventions
Bilateral erector spinae plane block (bupivacaine and ketamine)
Bilateral erector spinae plane block (bupivacaine) and transdermal fentanyl patch
Eligibility Criteria
You may qualify if:
- Patients undergoing laparoscopic colorectal surgery.
- American Society of Anesthesiologists (ASA) physical status I or II.
You may not qualify if:
- Known allergy to one of the study medications.
- Skin infections at the site of the needle puncture.
- Hepatic, renal or cardiac dysfunction.
- Patients diagnosed with obstructive sleep apnoea
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Ain-Shams University Hospitals
Cairo, Egypt
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, CARE PROVIDER
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor of Anesthesia and Intensive Care, Faculty of Medicine, Ain- shams University, Cairo, Egypt.
Study Record Dates
First Submitted
August 17, 2023
First Posted
August 23, 2023
Study Start
September 5, 2023
Primary Completion
July 22, 2025
Study Completion
July 22, 2025
Last Updated
February 18, 2026
Record last verified: 2026-02