Effect of Hebal and Synthetic Medicamentss on Enterococcus Feacalis

NCT06006663 | Unknown Phase 2

• 1 other identifier: eliminations of E.faecalis
• Study Type: interventional
• Target: 32
• Locations: 0 countries
• Sites: N/A

Brief Summary

this study aims to evaluate the antimicrobial efficacy of two synthetic (Ibuprofen, Modified triple antibiotic paste) and two herbal materials (Curcumin and Olive leaves extract) used as intracanal medication, against E.Faecalis in secondary endodontic infection cases.

Conditions

Effective Intracanal Medicaments Against Enterococcus Faecalis

Outcome Measures

Primary Outcomes (1)

• measurment of microbial reduction as result of applying synthetic and herbaal intracanal medicaments

  sample 1 will be taken after gutta percha removal sample 2 will be taken after cleaning and shaping sample 3 will be taken after apllying the intracanal medicament for one week

  time necessary for incubation of each sample is 24 hour

Study Arms (4)

group 1

ACTIVE COMPARATOR

ibuprofen as intracanal medicament

Drug: Ibuprofen 400 mg.

group 2

ACTIVE COMPARATOR

modified triple antibiotic paste as intracanal medicament

Drug: modified triple antibiotic paste

group 3

ACTIVE COMPARATOR

curcumin as intracanal medicament

Dietary Supplement: curcumin

group 4

ACTIVE COMPARATOR

olive leaves as intracanal medicament

Dietary Supplement: olive leaves extract

Interventions

Ibuprofen 400 mg. DRUG

synthetic intracanal medicament

group 1

modified triple antibiotic paste DRUG

synthetic intracanal medicament

Also known as: clindamycin, ciprofloxacin and metronidazole

group 2

curcumin DIETARY_SUPPLEMENT

herbal intracanal medicament

group 3

olive leaves extract DIETARY_SUPPLEMENT

herbal intracanal medicament

group 4

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Single rooted teeth.
• Teeth have clinical signs and symptoms of endodontic failure as sensitivity to percussion, pain, swelling or fistula.
• Teeth with radiographic features of endodontic failure as persistent periapical lesion or widening of periodontal ligament.

You may not qualify if:

• Teeth with fractures of the crown or root.
• Teeth with periodontal pocket deeper than 4mm.
• Teeth have procedural error like ledge, broken instrument, or perforation.

Sponsors & Collaborators

• Tanta University: lead

MeSH Terms

Interventions

Ibuprofen; Clindamycin; Ciprofloxacin; Metronidazole; Curcumin

Intervention Hierarchy (Ancestors)

Phenylpropionates; Acids, Carbocyclic; Carboxylic Acids; Organic Chemicals; Lincomycin; Lincosamides; Pyrrolidines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Glycosides; Carbohydrates; Fluoroquinolones; 4-Quinolones; Quinolones; Quinolines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Nitroimidazoles; Nitro Compounds; Imidazoles; Azoles; Diarylheptanoids; Heptanes; Alkanes; Hydrocarbons, Acyclic; Hydrocarbons; Catechols; Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic

Central Study Contacts

alaa essam abo laimon, demonstrator at university

CONTACT

01005690958; alaalamona@yahoo.com

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Demonstrator , Endodontic department,Faculty of dentistry,Tanta university

Study Record Dates

• First Submitted: August 17, 2023
• First Posted: August 23, 2023
• Study Start: August 26, 2023
• Primary Completion: October 5, 2023
• Study Completion: December 10, 2023
• Last Updated: August 23, 2023

Record last verified: 2023-08