Effect of Pharmacokinetics in Healthy Chinese Subjects

NCT06005714 | Completed Phase 1

• 1 other identifier: JT001-018-I
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a single-center, open label, self-controlled phase I clinical study, to evaluate the effects of clarithromycin or cyclosporine on pharmacokinetics of deuterium hydrobromide ramidvir tablets in healthy Chinese subjects.

Conditions

The Effects of Clarithromycin or Cyclosporine on Pharmacokinetics of Deuterium Hydrobromide Ramidvir Tablets in Healthy Chinese Subjects

Outcome Measures

Primary Outcomes (2)

• AUC0-t of 116-N1

  Area under the curve from time zero to the time of the t(AUC0-t ) of 116-N1

  At pre-defined intervals up to 14 days

• Maximum Plasma Concentration (Cmax) of 116-N1

  Maximum Plasma Concentration (Cmax) of 116-N1

  At pre-defined intervals up to 14 days

Secondary Outcomes (5)

• Half-life(T1/2) of 116-N1

  At pre-defined intervals up to 14 days

• Clearance(CL) of 116-N1

  At pre-defined intervals up to 14 days

• Tmax of 116-N1

  At pre-defined intervals up to 14 days

• Vz/F of 116-N1

  At pre-defined intervals up to 14 days

• Incidence and severity of adverse events including serious adverse events

  Up to 18 days

Study Arms (2)

The effects of clarithromycin on pharmacokinetics of deuterium hydrobromide ramidvir tablets

EXPERIMENTAL

Drug: Mindeudesivir hydrobromide tablets and Clarithromycin tablets; Drug: Mindeudesivir hydrobromide tablets and Cyclosporine softgels

The effects of cyclosporine on pharmacokinetics of deuterium hydrobromide ramidvir tablets

EXPERIMENTAL

Drug: Mindeudesivir hydrobromide tablets and Clarithromycin tablets; Drug: Mindeudesivir hydrobromide tablets and Cyclosporine softgels

Interventions

Mindeudesivir hydrobromide tablets and Clarithromycin tablets DRUG

Mindeudesivir hydrobromide tablets are administered once at D1 and D4, and clarithromycin tablets are administered twice from D1 to D10.

The effects of clarithromycin on pharmacokinetics of deuterium hydrobromide ramidvir tablets; The effects of cyclosporine on pharmacokinetics of deuterium hydrobromide ramidvir tablets

Mindeudesivir hydrobromide tablets and Cyclosporine softgels DRUG

Mindeudesivir hydrobromide tablets are administered once at D1 and D4, and cyclosporine sofgels are administered once at D4.

The effects of clarithromycin on pharmacokinetics of deuterium hydrobromide ramidvir tablets; The effects of cyclosporine on pharmacokinetics of deuterium hydrobromide ramidvir tablets

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age: 18 years old ≤ age ≤ 45 years old; Gender is not limited;
• Weight: male ≥ 50 kg, female ≥ 45 kg; Body mass index (BMI) in the range of 19-26 kg/m2 (including 19 and 26);
• Good health status, that is, vital signs, physical examination, laboratory tests, electrocardiogram and ultrasound examination are normal or abnormal and have no clinical significance;
• Participants who were able to take effective contraceptive measures during the study and within 3 months after the last dose of investigational product;
• Participants who could fully understand the purpose, content and possible adverse reactions of this study, voluntarily participate in the clinical study and sign the written informed consent form, and were able to complete the entire study process and comply with the study regulations in accordance with the requirements of the study.

You may not qualify if:

• Known history of allergy to the test preparation and any of its components or related preparations;
• Subjects with allergic diseases or allergic constitutions;
• Those who have clear diseases of the central nervous system, cardiovascular system, digestive system, respiratory system, urinary system, blood system, metabolic disorders, etc., and require medical intervention or other diseases that are not suitable for participating in clinical trials (such as psychiatric history, etc.);
• Those who have donated blood or lost blood ≥ 400 mL within 3 months before enrollment, or have a history of blood product use;
• Those who have participated in clinical trials of other drugs and taken experimental drugs within 3 months before enrollment;
• Those who have used any prescription drugs, over-the-counter drugs, Chinese herbal medicines or health supplements within 2 weeks before screening;
• Those who have used any vaccine within 2 weeks prior to screening.
• Those who have previously undergone surgery (such as major gastrectomy surgery) that may affect drug absorption, distribution, metabolism, or excretion, or may have surgery or hospitalization plans during the estimated test;
• Those with a history of drug dependence or abuse within 1 year before screening, or a positive urine drug screening test;
• Those who have used P-gp or BCRP strong inhibitors within 2 weeks before screening (see Annex 6 of Section 10.6 for details);
• Those who have ingested grapefruit juice/grapefruit juice, foods or drinks rich in methylxanthines (such as coffee, tea, cola, chocolate, functional drinks) within 48 hours before administration, or strenuous exercise and other factors that affect drug absorption, distribution, metabolism, excretion and other factors;
• Alcohol addict within 1 year prior to screening, drinking at least 2 times a day or more than 14 units per week, or keen on alcoholism (1 unit≈ 200 mL of beer with 5% alcohol or 25 mL of spirits with 40% alcohol or 85 mL of wine with 12% alcohol);
• Those who smoked cigarettes within 1 year before screening, and smoked more than 10 cigarettes or the same amount of tobacco per day;
• Those who cannot quit smoking or alcohol during the trial;
• Hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (Anti-HCV), treponemal antibody and HIV antibody positive;

Sponsors & Collaborators

• Shanghai Vinnerna Biosciences Co., Ltd.: lead

Study Sites (1)

Zhengzhou Sixth People's Hospital

Zhengzhou, Henan, 450000, China

Location

MeSH Terms

Interventions

Clarithromycin

Intervention Hierarchy (Ancestors)

Erythromycin; Macrolides; Polyketides; Lactones; Organic Chemicals

Study Officials

• Shuang Li

  Zhengzhou Sixth People's Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 15, 2023
• First Posted: August 22, 2023
• Study Start: August 15, 2023
• Primary Completion: October 31, 2023
• Study Completion: October 31, 2023
• Last Updated: June 29, 2025

Record last verified: 2025-06

Locations

CN (1)