Normal Reference Values in Han Adults of Skin Thickness and Blood Flow by High-frequency Ultrasound

NCT06000163 | Unknown DMC

• 1 other identifier: NOVAS-HFUS-01
• Study Type: observational
• Target: 540
• Locations: 0 countries
• Sites: N/A

Brief Summary

In recent years, high-frequency ultrasound has become a new non-invasive tool for the diagnosis of skin diseases, aesthetic medicine and preoperative and postoperative evaluation due to its higher resolution. The purpose of this multi-center Study is to establish the normal reference values of skin thickness and blood flow parameters by high-frequency ultrasound in Chinese Han adults, and to explore the influencing factors, so as to provide quantitative reference for the evaluation of facial skin aging degree and cosmetic treatment.

Conditions

Healthy Volunteer; Skin

Keywords

skin thickness; dermal blood flow; high-frequency ultrasound

Outcome Measures

Primary Outcomes (1)

• Dermal thickness

  Dermal thickness reflects the change in skin structure and can be used to assess skin aging.

  1 day

Secondary Outcomes (1)

• Blood flow velocity of dermal artery

  1 day

Interventions

high-frequency ultrasound DEVICE

The volunteers will be given a high-frequency ultrasound examination of the skin, which is non-invasive, and skin thickness and blood flow parameters will be measured.

Eligibility Criteria

• Age: 18 Years - 79 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Chinese healthy Han adults

You may qualify if:

• Han nationality;
• Ages 18-79;
• Normal blood pressure (139-90/89-60mmHg);
• Body mass index \< 30 kg/m2;
• Blood routine, fasting blood glucose, blood lipid, liver and kidney function, electrocardiogram were normal;
• No history of skin disease, connective tissue disease, cardiovascular disease, diabetes, severe liver and kidney dysfunction.
• No history of drug use affecting cardiovascular system.

You may not qualify if:

• People with skin diseases (such as eczema, psoriasis, scleroderma, etc.);
• Any skin disease at the test site (such as dermatitis, acne, breakages, previous skin lesions, etc.);
• chronic systemic diseases;
• Use corticosteroid drugs or immunosuppressants;
• Pregnant or lactating women;
• People who have been exposed to ultraviolet radiation for a long time or have a history of sun exposure within 3 months;
• The examined skin area has been previously treated with other methods;
• Unable to cooperate with the inspector.

Sponsors & Collaborators

• First Hospital of China Medical University: lead

Study Officials

• Lixin Jiang, PHD

  Shanghai Jiao Tong University School of Medicine

  PRINCIPAL INVESTIGATOR

• Xinhua Ye, PHD

  The First Affiliated Hospital with Nanjing Medical University

  PRINCIPAL INVESTIGATOR

• WeiDong Ren, PHD

  Shengjing Hospital

  PRINCIPAL INVESTIGATOR

• Xin Guan, PHD

  Tianjin Chest Hospital

  PRINCIPAL INVESTIGATOR

• Hongning Yin, PHD

  The Second Hospital of Hebei Medical University

  PRINCIPAL INVESTIGATOR

• Xiaoshan Zhang, PHD

  The Affiliated Hospital of Inner Mongolia Medical University

  PRINCIPAL INVESTIGATOR

• Yuhong Zhang, PHD

  The Second Affiliated Hospital of Dalian Medical University

  PRINCIPAL INVESTIGATOR

• Qingxiong Yue, PHD

  Dalian Municipal Central Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Chunyan Ma, PHD

CONTACT

13998816448; cmu1h_mcy@126.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief of Cardiovascular Ultrasound

Study Record Dates

• First Submitted: July 23, 2023
• First Posted: August 21, 2023
• Study Start: September 1, 2023
• Primary Completion: September 30, 2024
• Study Completion: September 30, 2025
• Last Updated: August 21, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share