Trials Sponsors Conditions Drugs Pricing

Conditions

Epithelial Mesenchymal Transition Long Noncoding RNA Periodontal Disease, AVDC Stage 3and 4

Outcome Measures

Primary Outcomes (1)

determining the relative expression of lncRNAs (NEAT1 and MALAT1) in healthy and diseased periodontal tissue.
reverse transcription real time polymerase chain reaction
one year

Secondary Outcomes (1)

determine the expression of EMT-related genes (E-cadherin, Vimentin, β-catenin, and Snail1), in healthy and diseased tissues, and their correlation with lncRNAs and clinical parameters.
one year

Study Arms (2)

control group

-healthy groups/without the condition

study group

-diseased group-/with the condition (periodontitis)

Other: periodontitis challenge

Interventions

periodontitis challengeOther

control will be compared to diseased group suffering from periodontal disease.

study group

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Sexall

Healthy VolunteersYes

Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Patients diagnosed with periodontitis, and healthy periodontal tissues will be recruited at the College of Dentistry/University of Baghdad and Al Sadir specialized dental center/Al-Risafa directorate/ Ministry of Health. No age or gender restriction.

You may qualify if:

Patients with no history of systemic disease e.g., diabetes.

Sponsors & Collaborators

Ali A Abdulkareem
Otherlead

Study Sites (1)

saif mohammed T AL Mufti

Baghdad, 964, Iraq

Biospecimen

Retention: SAMPLES WITH DNA

gingival tissue byproduct of resective periodontal surgery

MeSH Terms

Conditions

Periodontal Diseases

Condition Hierarchy (Ancestors)

Mouth DiseasesStomatognathic Diseases

Enrollment

48 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: CROSS SECTIONAL
Sponsor Type: OTHER
Responsible Party: SPONSOR INVESTIGATOR
PI Title: assistant professor- department of periodontics-college of dentistry- Baghdad university

Study Record Dates

First Submitted

August 8, 2023

First Posted

August 16, 2023

Study Start

February 14, 2022

Actual (reported)

The Potential Association of Long Non-coding RNA (NEAT1 and MALAT1) in the Process of Epithelial-mesenchymal Transition in Periodontitis

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (2)

control group

study group

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (2)

control group

study group

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations