Evaluation of Patients With Covid-19 Infection in Terms of Severity of Osteoprosis

NCT05993130 | Completed

• 1 other identifier: Kayseri City Hospital
• Study Type: observational
• Target: 55
• Locations: 1 country
• Sites: 1

Brief Summary

Osteoporosis is a condition characterized by decreased bone strength and an increased risk of fracture. Age, gender, body mass index, fragility fracture history, corticosteroid use, immobilization, smoking and alcohol use, endocrine pathologies besides inflammatory and infectious pathologies can also be effective in the development of osteoporosis. The aim of the study is to evaluate the effect of Covid-19 infection on the development of osteoporosis. In this study, bone mineral density (BMD) measurements of patients with Covid-19 infection were examined. For this, dual-energy x-ray absorptiometry (DEXA) measurement was used. A total of 55 patients were included in the study and data such as age, height, weight, comorbidities, drugs used, and treatment methods were recorded. Results showed that the time spent in the intensive care unit was associated with the femoral neck T score in DEXA measurements of patients with Covid-19 infection. The use of drugs such as alendronate, zolendronate, denosumab or teriparatide during the treatment process did not have a statistically significant effect on the lumbar and femur T scores.

Conditions

Severity of Osteoprosis

Outcome Measures

Primary Outcomes (1)

• Does the severity of osteoporosis increase in patients with Covid-19 infection?

  2020 August 2021 July

Interventions

The patients were not intervened. This is a retrospective study OTHER

The patients were not intervened. This is a retrospective study

Eligibility Criteria

• Age: 18 Years - 100 Years
• Gender Eligibility Details: Physically and anatomically female patients were included. There was no difference in the patients included in our study.
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Between August 2020 and July 2021, two separate excel files were created for the identification numbers of the patients who had DEXA measurements and the identification numbers of the patients who had covid. Then, common ID numbers were found in both excel files in the computer environment. Among these patients, female patients over the age of 18 who had dexa measurements twice before and after covid, with at least one year between two dexa measurements and at least one month after covid infection were included in the study.

You may qualify if:

• Female patients over the age of 18 who had dexa measurements twice before and after covid, with at least one year between two dexa measurements, and at least one month after covid infection were included in the study.

You may not qualify if:

• Under the age of 18, male patients, patients with a diagnosis other than Covid-19 infection that will affect bone metabolism between the two dexa shooting dates before and after covid, patients who use another drug other than covid treatment that will affect bone metabolism between the two dexa shooting dates before and after covid not included in the study

Sponsors & Collaborators

• Kayseri Education and Research Hospital: lead

Study Sites (1)

Kayseri City Hospital

Kayseri, Turkey (Türkiye)

Location

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: physical medicine and rehabilitation

Study Record Dates

• First Submitted: August 14, 2023
• First Posted: August 15, 2023
• Study Start: January 15, 2021
• Primary Completion: December 15, 2022
• Study Completion: December 15, 2022
• Last Updated: August 15, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)